Concepedia

Lyophilization Cycle Optimization

Lyophilization Cycle Optimization is a methodological framework within pharmaceutical process engineering that systematically refines the time-temperature-pressure parameters of a freeze-drying cycle to minimize processing duration and energy consumption while ensuring product quality, stability, and cake homogeneity.

56

Publications

2.9K

Citations

216

Authors

84

Institutions

Publications per year

2017–2026

21

Variants

Freeze-drying Cycle Optimization

Parents

Publications

56

Annealing to optimize the primary drying rate, reduce freezing‐induced drying rate heterogeneity, and determine T'g in pharmaceutical lyophilization

James A. Searles, John F. Carpenter, Theodore W. Randolph · Journal of Pharmaceutical Sciences · 2001 · 308 citations

, , +13

Lyophilization/Freeze Drying - An Review

Gr. Nireesha, Lakshmi S Divya, C. Sowmya et al. · International Journal of Novel Trends in Pharmaceutical Sciences · 2013 · 209 citations

, , +12

Protein formulation and lyophilization cycle design: Prevention of damage due to freeze-concentration induced phase separation

Martin Heller, John F. Carpenter, Theodore W. Randolph · Biotechnology and Bioengineering · 1999 · 162 citations

, , +17

An analysis of the lyophilization process using a sorption‐sublimation model and various operational policies

M. J. Millman, A.I. Liapis, Joseph M. Marchello · AIChE Journal · 1985 · 126 citations

, , +14

Advanced approach to build the design space for the primary drying of a pharmaceutical freeze‐drying process

Davide Fissore, Roberto Pisano, Antonello Barresi · Journal of Pharmaceutical Sciences · 2011 · 111 citations

, , +15

1–5 of 56

Authors

216

  1. RP
    Roberto Pisano

    Politecnico di Torino, Italy

    10 publications · 595 citations

    10

    h-index

  2. AB
    Antonello Barresi

    Politecnico di Torino, Italy

    9 publications · 589 citations

    9

    h-index

  3. DF
    Davide Fissore

    Politecnico di Torino, Italy

    9 publications · 544 citations

    9

    h-index

  4. AA
    Alina Alexeenko

    Purdue University West Lafayette, United States

    4 publications · 126 citations

    4

    h-index

  5. MT
    Masahito Takeuchi

    Daiichi-Sankyo (Japan), Japan

    3 publications · 74 citations

    3

    h-index

1–5 of 216

Institutions

84

  1. Politecnico di Torino

    Turin, Italy

    13 h-index

    45 publications

    2.5K citations

  2. Purdue University West Lafayette

    West Lafayette, United States

    5 h-index

    17 publications

    438 citations

  3. AbbVie (United States)

    North Chicago, United States

    4 h-index

    19 publications

    644 citations

  4. Daiichi-Sankyo (Japan)

    Tokyo, Japan

    3 h-index

    7 publications

    163 citations

  5. Toho University

    Tokyo, Japan

    3 h-index

    4 publications

    91 citations

  6. Daiichi Sankyo (United Kingdom)

    Chalfont Saint Peter, United Kingdom

    3 h-index

    9 publications

    222 citations

  7. Bristol-Myers Squibb (United States)

    New York, United States

    3 h-index

    15 publications

    381 citations

  8. Baxter (United States)

    Deerfield, United States

    3 h-index

    9 publications

    200 citations

1–8 of 84

Venues

  1. Journal of Pharmaceutical Sciences

    15 publications · 974 citations

    14

    h-index

  2. International Journal of Pharmaceutics

    7 publications · 163 citations

    7

    h-index

  3. AAPS PharmSciTech

    5 publications · 141 citations

    5

    h-index

  4. Drying Technology

    4 publications · 204 citations

    4

    h-index

  5. Industrial & Engineering Chemistry Research

    3 publications · 87 citations

    3

    h-index

1–5