Concepedia

Liver Humanization

Liver Humanization is a methodological approach in biomedical research that involves the engraftment of human hepatocytes or genetic elements into animal models to reconstitute a functional human liver system, thereby enabling the in vivo study of human-specific liver physiology, metabolism, and disease.

17

Publications

1.6K

Citations

164

Authors

76

Institutions

Publications per year

2017–2026

7

Variants

Hepatic Humanization

Parents

Publications

17

Near Completely Humanized Liver in Mice Shows Human-Type Metabolic Responses to Drugs

Chise Tateno, Yasumi Yoshizane, Naomi Saito et al. · American Journal Of Pathology · 2004 · 545 citations

, , +12

The reconstituted ‘humanized liver’ in TK-NOG mice is mature and functional

Masami Hasegawa, Kenji Kawai, T Mitsui et al. · Biochemical and Biophysical Research Communications · 2011 · 317 citations

, , +14

Humanized mice with ectopic artificial liver tissues

Alice A. Chen, David Thomas, Luvena L. Ong et al. · Proceedings of the National Academy of Sciences · 2011 · 157 citations · Full text

, , +17

Generation of Novel Chimeric Mice with Humanized Livers by Using Hemizygous cDNA-uPA/SCID Mice

Chise Tateno, Yosuke Kawase, Yoshimi Tobita et al. · PLoS ONE · 2015 · 138 citations · Full text

, , +15

Extensive double humanization of both liver and hematopoiesis in FRGN mice

Elizabeth M. Wilson, John Bial, Branden Tarlow et al. · Stem Cell Research · 2014 · 135 citations · Full text

, , +17

1–5 of 17

Authors

164

  1. CT
    Chise Tateno

    Hiroshima University, Japan

    4 publications · 729 citations

    4

    h-index

  2. HS
    Hiroshi Suemizu

    Central Institute for Experimental Animals, Japan

    3 publications · 450 citations

    3

    h-index

  3. KY
    Katsutoshi Yoshizato

    Hiroshima University, Japan

    2 publications · 563 citations

    2

    h-index

  4. KK
    Kenji Kawai

    Central Institute for Experimental Animals, Japan

    2 publications · 353 citations

    2

    h-index

  5. YZ
    Yun‐Wen Zheng

    Yokohama City University, Japan

    1 publications · 13 citations

    2

    h-index

1–5 of 164

Institutions

76

  1. Hiroshima University

    Hiroshima, Japan

    4 h-index

    16 publications

    6.3K citations

  2. Central Institute for Experimental Animals

    Kawasaki, Japan

    3 h-index

    17 publications

    3.3K citations

  3. PhoenixBio (Japan)

    Hiroshima, Japan

    3 h-index

    12 publications

    1.3K citations

  4. Showa Pharmaceutical University

    Tokyo, Japan

    2 h-index

    4 publications

    90 citations

  5. Yokohama City University

    Yokohama, Japan

    2 h-index

    7 publications

    91 citations

  6. Keio University

    Tokyo, Japan

    2 h-index

    5 publications

    1.1K citations

  7. Yecuris (United States)

    Portland, United States

    2 h-index

    6 publications

    694 citations

  8. Chinese Academy of Sciences

    Beijing, China

    2 h-index

    10 publications

    270 citations

1–8 of 76

Venues

  1. Drug Metabolism and Pharmacokinetics

    DMPK · 2 publications · 54 citations

    2

    h-index

  2. Biochemical and Biophysical Research Communications

    BBRC · 2 publications · 414 citations

    2

    h-index

  3. Annals of Surgery

    1 publications · 10 citations

    1

    h-index

  4. Materials Science and Engineering C

    1 publications · 23 citations

    1

    h-index

  5. American Journal Of Pathology

    AJP · 1 publications · 545 citations

    1

    h-index

1–5