Hiroki Ohshita

Generation of Novel Chimeric Mice with Humanized Livers by Using Hemizygous cDNA-uPA/SCID Mice

Chise Tateno, Yosuke Kawase, Yoshimi Tobita et al. · PLoS ONE · 2015 · 138 citations · Full text

Life Sciences, Biotechnology, Genetics +15

Prediction of In Vivo Hepatic Clearance and Half-Life of Drug Candidates in Human Using Chimeric Mice with Humanized Liver

Seigo Sanoh, Aya Horiguchi, Kazumi Sugihara et al. · Drug Metabolism and Disposition · 2011 · 80 citations

Pharmacy, Pharmacokinetics, Pharmacology +16

Predictability of plasma concentration–time curves in humans using single-species allometric scaling of chimeric mice with humanized liver

Seigo Sanoh, Yoichi Naritomi, Mami Fujimoto et al. · Xenobiotica · 2015 · 49 citations

Pharmacy, Pharmacokinetics, Pharmacology +13

Predictability of Metabolism of Ibuprofen and Naproxen Using Chimeric Mice with Human Hepatocytes

Seigo Sanoh, Aya Horiguchi, Kazumi Sugihara et al. · Drug Metabolism and Disposition · 2012 · 46 citations

Medicine, Pharmacokinetics, Pharmacology +15

Prediction of Human Disposition toward S-3H-Warfarin using Chimeric Mice with Humanized Liver

Tae Inoue, Kazumi Sugihara, Hiroki Ohshita et al. · Drug Metabolism and Pharmacokinetics · 2009 · 34 citations

Pharmacy, Pharmacokinetics, Pharmacology +16