Near Completely Humanized Liver in Mice Shows Human-Type Metabolic Responses to Drugs

Real time quantitative PCR.

Chris Heid, Junko Stevens, Kenneth J. Livak et al. · Genome Research · 1996 · 6.2K citations · Full text

Life Sciences, Biotechnology, Molecular Biology +13

Hepatitis C virus replication in mice with chimeric human livers

David F. Mercer, Dan Schiller, John F. Elliott et al. · Nature Medicine · 2001 · 877 citations

Life Sciences, Infectious Diseases, Microbiology +13

Repopulation of Mouse Liver With Human Hepatocytes And In Vivo Infection With Hepatitis B Virus

Maura Dandri, Martin R. Burda, É Török et al. · Hepatology · 2001 · 409 citations

Medicine, Infectious Diseases, Hepatology +12

Complete hepatic regeneration after somatic deletion of an albumin-plasminogen activator transgene

E P Sandgren, R D Palmiter, Janice L. Heckel et al. · Cell · 1991 · 385 citations

Engineering, Biochemistry, Genetics +14

Prediction of human hepatic clearance from in vivo animal experiments and in vitro metabolic studies with liver microsomes from animals and humans.

Y. Naritomi, Shigeyuki Terashita, Sumihisa Kimura et al. · PubMed · 2001 · 317 citations

Pharmacy, Pharmacokinetics, Pharmacology +17