Concepedia

Lineage Specification

Lineage Specification is a developmental biology process that defines the commitment of pluripotent stem cells to a particular cell fate by activating lineage-specific gene regulatory networks while suppressing alternative fates.

691

Publications

70.6K

Citations

5K

Authors

1.2K

Institutions

Publications per year

2017–2026

258

Parents

Publications

691

Matrix Elasticity Directs Stem Cell Lineage Specification

Adam J. Engler, Shamik Sen, H. Lee Sweeney et al. · Cell · 2006 · 13.7K citations · Full text

, , +10

Chromatin architecture reorganization during stem cell differentiation

Jesse R. Dixon, Inkyung Jung, Siddarth Selvaraj et al. · Nature · 2015 · 1.8K citations · Full text

, , +17

Whole-organism lineage tracing by combinatorial and cumulative genome editing

Aaron McKenna, Gregory M. Findlay, James A. Gagnon et al. · Science · 2016 · 801 citations · Full text

, , +14

Tet1 and Tet2 Regulate 5-Hydroxymethylcytosine Production and Cell Lineage Specification in Mouse Embryonic Stem Cells

Kian Peng Koh, Akiko Yabuuchi, Sridhar Rao et al. · Cell stem cell · 2011 · 784 citations · Full text

, , +16

Klf4 reverts developmentally programmed restriction of ground state pluripotency

Ge Guo, Jian Yang, Jennifer Nichols et al. · Development · 2009 · 775 citations · Full text

, , +17

1–5 of 691

Authors

5K

  1. AS
    Austin Smith

    Wellcome/MRC Cambridge Stem Cell Institute, United Kingdom

    9 publications · 1.5K citations

    9

    h-index

  2. JM
    Jesse Mager

    University of Massachusetts Amherst, United States

    7 publications · 180 citations

    7

    h-index

  3. JN
    Jennifer Nichols

    University of Cambridge, United Kingdom

    7 publications · 1.3K citations

    7

    h-index

  4. BZ
    Bin Zhou

    Center for Excellence in Molecular Cell Science, China

    6 publications · 452 citations

    6

    h-index

  5. TE
    Tariq Enver

    University College London, United Kingdom

    5 publications · 623 citations

    5

    h-index

1–5 of 5K

Institutions

1.2K

  1. Harvard University

    Cambridge, United States

    32 h-index

    135 publications

    18.2K citations

  2. University of Cambridge

    Cambridge, United Kingdom

    29 h-index

    136 publications

    15.8K citations

  3. Howard Hughes Medical Institute

    Chevy Chase, United States

    24 h-index

    80 publications

    17K citations

  4. Wellcome/MRC Cambridge Stem Cell Institute

    Cambridge, United Kingdom

    20 h-index

    99 publications

    13.9K citations

  5. Chinese Academy of Sciences

    Beijing, China

    19 h-index

    162 publications

    8.1K citations

  6. University of Chinese Academy of Sciences

    Beijing, China

    18 h-index

    103 publications

    6.6K citations

  7. Centre National de la Recherche Scientifique

    Paris, France

    17 h-index

    92 publications

    7.1K citations

  8. Inserm

    Paris, France

    16 h-index

    113 publications

    10.2K citations

1–8 of 1.2K

Venues

  1. Development

    51 publications · 6.5K citations

    39

    h-index

  2. Nature Communications

    40 publications · 3.2K citations

    31

    h-index

  3. PLoS ONE

    33 publications · 1.7K citations

    24

    h-index

  4. Cell Reports

    26 publications · 2.4K citations

    24

    h-index

  5. Proceedings of the National Academy of Sciences

    PNAS · 20 publications · 2.2K citations

    20

    h-index

1–5