Accurate classification of BRCA1 variants with saturation genome editing

Gregory M. Findlay, Riza M. Daza, Beth Martin, +7

Nature

GeneticsComputational GenomicsBrca1 VariantsGenome AnalysisGenomics +4

Whole-organism lineage tracing by combinatorial and cumulative genome editing

Aaron McKenna, Gregory M. Findlay, James A. Gagnon, +3

Science

Saturation editing of genomic regions by multiplex homology-directed repair

Gregory M. Findlay, Evan A. Boyle, Ronald J. Hause, +2

Nature

Genome InstabilityGeneticsDna ReplicationGene EditingMedicine +2

Dephosphorylation of the nuclear factor of activated T cells (NFAT) transcription factor is regulated by an RNA-protein scaffold complex

Sonia Sharma, Gregory M. Findlay, Hozefa S. Bandukwala, +7

Proceedings of the National Academy of Sciences

An siRNA screen for NFAT activation identifies septins as coordinators of store-operated Ca2+ entry

Sonia Sharma, Ariel Quintana, Gregory M. Findlay, +6

Nature

Protein SecretionSignal TransductionMolecular PhysiologyBiochemistryNatural Sciences +7

Membrane dynamics of dividing cells imaged by lattice light-sheet microscopy

François Aguet, Srigokul Upadhyayula, Raphaël Gaudin, +15

Molecular Biology of the Cell

MicroscopyCytoskeletonCell BiophysicsCellular PhysiologyMembrane Dynamics +17

CRISPR/Cas9-Mediated Scanning for Regulatory Elements Required for HPRT1 Expression via Thousands of Large, Programmed Genomic Deletions

Molly Gasperini, Gregory M. Findlay, Aaron McKenna, +5

The American Journal of Human Genetics

Off-target EffectMedicineGeneticsNatural SciencesGenetic Engineering +10

spinDrop: a droplet microfluidic platform to maximise single-cell sequencing information content

Joachim De Jonghe, Tomasz S. Kamiński, David B. Morse, +9

Nature Communications

Systematic Dissection of Coding Exons at Single Nucleotide Resolution Supports an Additional Role in Cell-Specific Transcriptional Regulation

Ramon Y. Birnbaum, Rupali P Patwardhan, Mee J. Kim, +8

PLoS Genetics

GeneticsGenomic MechanismGene CharacterizationTranscriptional RegulationGene Structure +16

Saturation genome editing maps the functional spectrum of pathogenic VHL alleles

Megan Buckley, Chloé Terwagne, Athina Ganner, +15

Nature Genetics