Concepedia

Lead Compound Simplification

Lead Compound Simplification is a computational or methodological approach in synthetic accessibility optimization that systematically reduces molecular complexity of bioactive compounds while preserving essential pharmacophoric features to enhance synthetic feasibility.

5

Publications

149

Citations

41

Authors

7

Institutions

Publications per year

2017–2026

1

Parents

Publications

5

Opportunities for New Chemical Libraries: Unnatural Biopolymers and Diversomers

Rob M. J. Liskamp · Angewandte Chemie International Edition in English · 1994 · 81 citations

, , +11

Rational optimization of a HIV-1 Tat inhibitor: Rapid progress on combinatorial lead structures

Thomas Klimkait, Eduard Felder, Geneviève Albrecht et al. · Biotechnology and Bioengineering · 1999 · 24 citations

, , +17

Facile and divergent optimization of chromazonarol enabled the identification of simplified drimane meroterpenoids as novel pharmaceutical leads

Xia Wang, Nvdan Hu, Wenlong Kong et al. · European Journal of Medicinal Chemistry · 2021 · 17 citations

, , +13

Novel CGRP receptor antagonists through a design strategy of target simplification with addition of molecular flexibility

Michael R. Wood, Kathy M. Schirripa, June J. Kim et al. · Bioorganic & Medicinal Chemistry Letters · 2009 · 14 citations · Full text

, , +17

Pyrazole inhibitors of HMG-CoA reductase: An attempt to dramatically reduce synthetic complexity through minimal analog re-design

Scott D. Larsen, Toni-Jo Poel, Kevin J. Filipski et al. · Bioorganic & Medicinal Chemistry Letters · 2007 · 13 citations · Full text

, , +17

1–5 of 5

Authors

41

  1. JP
    Joseph P. Vacca

    United States Military Academy, United States

    1 publications · 14 citations

    1

    h-index

  2. EF
    Eduard Felder

    Nerviano Medical Sciences, Italy

    1 publications · 24 citations

    1

    h-index

  3. NH
    Nvdan Hu

    Guizhou University, China

    1 publications · 17 citations

    1

    h-index

  4. BD
    Bradley D. Tait

    Pfizer (United States), United States

    1 publications · 13 citations

    1

    h-index

  5. LD
    Lisa Dillon

    Pfizer (United States), United States

    1 publications · 13 citations

    1

    h-index

1–5 of 41

Institutions

7

  1. Guizhou University

    Guiyang, China

    1 h-index

    5 publications

    85 citations

  2. University of Basel

    Basel, Switzerland

    1 h-index

    1 publications

    24 citations

  3. Nanjing Agricultural University

    Nanjing, China

    1 h-index

    2 publications

    34 citations

  4. Utrecht University

    Utrecht, The Netherlands

    1 h-index

    1 publications

    81 citations

  5. Pfizer (United States)

    New York, United States

    1 h-index

    15 publications

    195 citations

  6. United States Military Academy

    West Point, United States

    1 h-index

    4 publications

    56 citations

  7. Novartis (Switzerland)

    Basel, Switzerland

    1 h-index

    3 publications

    72 citations

  8. University of Jordan

    Amman, Jordan

    1 publications

    10 citations

1–8 of 7

Venues

  1. Bioorganic & Medicinal Chemistry Letters

    2 publications · 27 citations

    2

    h-index

  2. 1

    h-index

  3. European Journal of Medicinal Chemistry

    1 publications · 17 citations

    1

    h-index

  4. Biotechnology and Bioengineering

    1 publications · 24 citations

    1

    h-index

1–5