Joseph G. Bruno

Discovery of the Dual Orexin Receptor Antagonist [(7<i>R</i>)-4-(5-Chloro-1,3-benzoxazol-2-yl)-7-methyl-1,4-diazepan-1-yl][5-methyl-2-(2<i>H</i>-1,2,3-triazol-2-yl)phenyl]methanone (MK-4305) for the Treatment of Insomnia

Christopher D. Cox, Michael J. Breslin, David B. Whitman et al. · Journal of Medicinal Chemistry · 2010 · 367 citations · Full text

Psychotropic Medication, Pharmacotherapy, Primary Insomnia +17

Formulation and Antitumor Activity Evaluation of Nanocrystalline Suspensions of Poorly Soluble Anticancer Drugs

Elaine Merisko‐Liversidge, Pramod P. Sarpotdar, Joseph G. Bruno et al. · Pharmaceutical Research · 1996 · 231 citations

Discovery of a Potent, CNS‐Penetrant Orexin Receptor Antagonist Based on an <i>N</i>,<i>N</i>‐Disubstituted‐1,4‐diazepane Scaffold that Promotes Sleep in Rats

David B. Whitman, Christopher D. Cox, Michael J. Breslin et al. · ChemMedChem · 2009 · 71 citations

Discovery of 5′′‐Chloro‐<i>N</i>‐[(5,6‐dimethoxypyridin‐2‐yl)methyl]‐2,2′:5′,3′′‐terpyridine‐3′‐carboxamide (MK‐1064): A Selective Orexin 2 Receptor Antagonist (2‐SORA) for the Treatment of Insomnia

Anthony J. Roecker, Swati P. Mercer, John D. Schreier et al. · ChemMedChem · 2013 · 65 citations

Structure-Based Design and Synthesis of 1,3-Oxazinan-2-one Inhibitors of 11β-Hydroxysteroid Dehydrogenase Type 1

Zhenrong Xu, Colin M. Tice, Wei Zhao et al. · Journal of Medicinal Chemistry · 2011 · 40 citations · Full text

Molecular Pharmacology, Medicinal Chemistry, Cellular Potency +14