Concepedia

Synthetic Accessibility Optimization

Synthetic Accessibility Optimization is a strategic process in lead optimization that systematically enhances the feasibility and efficiency of chemical synthesis by minimizing structural complexity and practical barriers associated with the preparation of candidate drug molecules.

41

Publications

2.3K

Citations

187

Authors

78

Institutions

Publications per year

2017–2026

22

Parents

Children

Publications

41

Bioisosteric Replacement and Scaffold Hopping in Lead Generation and Optimization

Sarah R. Langdon, Peter Ertl, Nathan Brown · Molecular Informatics · 2010 · 231 citations

, , +10

SYNOPSIS:  SYNthesize and OPtimize System in Silico

H. Maarten Vinkers, Marc R. de Jonge, Frederik F. D. Daeyaert et al. · Journal of Medicinal Chemistry · 2003 · 229 citations · Full text

, , +15

Structure and reaction based evaluation of synthetic accessibility

Krisztina Boda, Thomas Seidel, Johann Gasteiger · Journal of Computer-Aided Molecular Design · 2007 · 185 citations

, , +6

Synthesis and Tunability of Highly Electron-Accepting, N-Benzylated “Phosphaviologens”

Monika Stolar, Javier Borau‐Garcia, Mark Toonen et al. · Journal of the American Chemical Society · 2015 · 147 citations · Full text

, , +12

Making the SF<sub>5</sub> Group More Accessible: A Gas‐Reagent‐Free Approach to Aryl Tetrafluoro‐λ<sup>6</sup>‐sulfanyl Chlorides

Cody Ross Pitts, Dustin Bornemann, Phil Liebing et al. · Angewandte Chemie International Edition · 2018 · 113 citations

, , +9

1–5 of 41

Authors

187

  1. CR
    Cody Ross Pitts

    Johns Hopkins University, United States

    2 publications · 188 citations

    2

    h-index

  2. YB
    Yoshua Bengio

    Université de Montréal, Canada

    2 publications · 95 citations

    2

    h-index

  3. SL
    Shengchao Liu

    University of Wisconsin–Madison, United States

    2 publications · 95 citations

    2

    h-index

  4. YP
    Yashaswi Pathak

    International Institute of Information Technology, Hyderabad, India

    2 publications · 95 citations

    2

    h-index

  5. SN
    Sufeng Niu

    LinkedIn (United States), United States

    2 publications · 95 citations

    2

    h-index

1–5 of 187

Institutions

78

  1. Friedrich-Alexander-Universität Erlangen-Nürnberg

    Erlangen, Germany

    2 h-index

    4 publications

    573 citations

  2. Universitätsklinikum Erlangen

    Erlangen, Germany

    2 h-index

    2 publications

    203 citations

  3. University of Washington

    Seattle, United States

    1 h-index

    1 publications

    85 citations

  4. Institute of Chemical Technology

    Mumbai, India

    1 h-index

    1 publications

    24 citations

  5. University of Houston

    Houston, United States

    1 h-index

    2 publications

    60 citations

  6. Utrecht University

    Utrecht, The Netherlands

    1 h-index

    9 publications

    2.1K citations

  7. Guangdong Laboratory Animals Monitoring Institute

    Guangzhou, China

    1 h-index

    2 publications

    44 citations

  8. Chinese Academy of Sciences

    Beijing, China

    1 h-index

    1 publications

    22 citations

1–8 of 78

Venues

  1. Angewandte Chemie International Edition

    5 publications · 304 citations

    5

    h-index

  2. Journal of Chemical Information and Modeling

    JCIM · 4 publications · 170 citations

    4

    h-index

  3. ACS Catalysis

    2 publications · 41 citations

    2

    h-index

  4. ACS Medicinal Chemistry Letters

    2 publications · 30 citations

    2

    h-index

  5. Journal of Computer-Aided Molecular Design

    2 publications · 203 citations

    2

    h-index

1–5