Opportunities for New Chemical Libraries: Unnatural Biopolymers and Diversomers

Abstract

The search for lead compounds may well be simplified by libraries of unnatural compounds, whose lead compounds may require less extensive modifications for the development of drug candidates than those derived from peptide and oligonucleotide libraries. An oligocarbamate library described by Cho et al. and a benzodiazepine library proposed by Hobbs DeWitt et al. should point the way to a large number of libraries.