Concepedia

Intrinsic Pathway

The Intrinsic Pathway is a coagulation cascade mechanism, classified within hemostasis, that initiates blood clotting through contact activation of factor XII in response to vascular subendothelial collagen exposure, distinguishing it from the extrinsic pathway by its factor-driven, slower activation sequence independent of tissue factor.

366

Publications

25.4K

Citations

1.6K

Authors

485

Institutions

Publications per year

2017–2026

49

Variants

Contact Activation Pathway

Parents

Children

Publications

366

Waterfall Sequence for Intrinsic Blood Clotting

Earl W. Davie, Oscar D. Ratnoff · Science · 1964 · 1.1K citations

, , +10

Targeting of αv integrin identifies a core molecular pathway that regulates fibrosis in several organs

Neil C. Henderson, Thomas D. Arnold, Yoshio Katamura et al. · Nature Medicine · 2013 · 874 citations · Full text

, , +16

The first comprehensive and quantitative analysis of human platelet protein composition allows the comparative analysis of structural and functional pathways

Julia M. Burkhart, Marc Vaudel, Stepan Gambaryan et al. · Blood · 2012 · 774 citations · Full text

, , +15

High Levels of Coagulation Factor XI as a Risk Factor for Venous Thrombosis

Joost C.M. Meijers, Winnie L.H. Tekelenburg, Bonno N. Bouma et al. · New England Journal of Medicine · 2000 · 695 citations

, , +12

Defective thrombus formation in mice lacking coagulation factor XII

Thomas Renné, Miroslava Požgajová, Sabine Grüner et al. · The Journal of Experimental Medicine · 2005 · 675 citations · Full text

, , +17

1–5 of 366

Authors

1.6K

  1. JC
    Joost C.M. Meijers

    Amsterdam UMC Location University of Amsterdam, Netherlands

    12 publications · 1.7K citations

    12

    h-index

  2. BN
    Bonno N. Bouma

    Utrecht University, Netherlands

    11 publications · 1.8K citations

    11

    h-index

  3. BN
    Bernhard Nieswandt

    University of Würzburg, Germany

    7 publications · 1.6K citations

    7

    h-index

  4. TR
    Thomas Renné

    University Medical Center Hamburg-Eppendorf, Germany

    7 publications · 1.8K citations

    7

    h-index

  5. DG
    David Gailani

    Vanderbilt University, United States

    7 publications · 1.3K citations

    7

    h-index

1–5 of 1.6K

Institutions

485

  1. University of North Carolina at Chapel Hill

    Chapel Hill, United States

    11 h-index

    48 publications

    2.2K citations

  2. Lund University

    Lund, Sweden

    9 h-index

    37 publications

    2.4K citations

  3. Amsterdam UMC Location University of Amsterdam

    Amsterdam, The Netherlands

    9 h-index

    35 publications

    4.4K citations

  4. Harvard University

    Cambridge, United States

    9 h-index

    22 publications

    2.1K citations

  5. Karolinska Institutet

    Stockholm, Sweden

    8 h-index

    41 publications

    6.3K citations

  6. University of California San Diego

    San Diego, United States

    8 h-index

    37 publications

    2.1K citations

  7. Dutch Blood Transfusion Society

    Amsterdam, Netherlands

    7 h-index

    14 publications

    1.4K citations

  8. Johannes Gutenberg University Mainz

    Mainz, Germany

    7 h-index

    13 publications

    1.1K citations

1–8 of 485

Venues

  1. Thrombosis and Haemostasis

    46 publications · 2K citations

    26

    h-index

  2. Journal of Biological Chemistry

    JBC · 22 publications · 1.7K citations

    22

    h-index

  3. PubMed

    Repository · 21 publications · 1K citations

    17

    h-index

  4. Blood

    18 publications · 2.1K citations

    15

    h-index

  5. Arteriosclerosis Thrombosis and Vascular Biology

    14 publications · 1.1K citations

    13

    h-index

1–5