Concepedia

Hydroxylation Reactions

Hydroxylation Reactions is a type of microbial biotransformation reaction in which a hydroxyl group (–OH) is introduced into an organic substrate, typically mediated by enzyme systems such as monooxygenases or cytochrome P450 enzymes, thereby increasing the substrate's polarity and often facilitating subsequent metabolic transformations.

2.9K

Publications

170.2K

Citations

9.8K

Authors

1.9K

Institutions

Publications per year

2017–2026

380

Parents

Publications

2.9K

C. elegans EGL-9 and Mammalian Homologs Define a Family of Dioxygenases that Regulate HIF by Prolyl Hydroxylation

Andrew Epstein, Jonathan Gleadle, Luke A. McNeill et al. · Cell · 2001 · 3.3K citations · Full text

, , +9

5-Hydroxymethylfurfural (HMF) as a building block platform: Biological properties, synthesis and synthetic applications

Andreia A. Rosatella, Svilen P. Simeonov, Raquel F. M. Frade et al. · Green Chemistry · 2011 · 1.6K citations

, , +15

Asparagine Hydroxylation of the HIF Transactivation Domain: A Hypoxic Switch

David Lando, Daniel J. Peet, Dean A. Whelan et al. · Science · 2002 · 1.5K citations

, , +14

The Catalytic Pathway of Cytochrome P450cam at Atomic Resolution

Ilme Schlichting, Joel Berendzen, Kelvin Chu et al. · Science · 2000 · 1.3K citations

, , +14

Impaired hydroxylation of 5-methylcytosine in myeloid cancers with mutant TET2

Myunggon Ko, Yun Huang, A. Jankowska et al. · Nature · 2010 · 1.3K citations

, , +16

1–5 of 2.9K

Authors

9.8K

  1. SP
    Sam P. de Visser

    University of Manchester, United Kingdom

    33 publications · 3.4K citations

    25

    h-index

  2. SS
    Sason Shaik

    Hebrew University of Jerusalem, Israel

    22 publications · 3.3K citations

    21

    h-index

  3. MJ
    Minor J. Coon

    University of Michigan, United States

    22 publications · 3.1K citations

    21

    h-index

  4. DK
    Devesh Kumar

    Babasaheb Bhimrao Ambedkar University, India

    20 publications · 2.6K citations

    19

    h-index

  5. FP
    F. Peter Guengerich

    Vanderbilt University, United States

    18 publications · 1.8K citations

    17

    h-index

1–5 of 9.8K

Institutions

1.9K

  1. University of Michigan

    Ann Arbor, United States

    39 h-index

    163 publications

    17.8K citations

  2. Chinese Academy of Sciences

    Beijing, China

    36 h-index

    282 publications

    13.8K citations

  3. Centre National de la Recherche Scientifique

    Paris, France

    34 h-index

    277 publications

    17.7K citations

  4. University of Minnesota

    Minneapolis, United States

    29 h-index

    128 publications

    11.4K citations

  5. National Institutes of Health

    Bethesda, United States

    28 h-index

    128 publications

    11K citations

  6. Karolinska Institutet

    Stockholm, Sweden

    26 h-index

    82 publications

    4.5K citations

  7. Stanford University

    Stanford, United States

    26 h-index

    122 publications

    10.8K citations

  8. University of Manchester

    Manchester, United Kingdom

    22 h-index

    74 publications

    5.7K citations

1–8 of 1.9K

Venues

  1. Journal of the American Chemical Society

    JACS · 166 publications · 16.1K citations

    79

    h-index

  2. Journal of Biological Chemistry

    JBC · 165 publications · 17.4K citations

    74

    h-index

  3. Biochemistry

    79 publications · 4.1K citations

    39

    h-index

  4. Angewandte Chemie International Edition

    51 publications · 4.2K citations

    37

    h-index

  5. Proceedings of the National Academy of Sciences

    PNAS · 33 publications · 6.1K citations

    33

    h-index

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