Concepedia

Guide Rna Specificity

Guide RNA Specificity is a metric that quantifies the extent to which a guide RNA directs CRISPR-associated nucleases exclusively to the intended genomic target site, minimizing off-target binding and cleavage.

178

Publications

33.3K

Citations

1.1K

Authors

317

Institutions

Publications per year

2017–2026

110

Parents

Publications

178

RNA-Guided Human Genome Engineering via Cas9

Prashant Mali, Luhan Yang, Kevin M. Esvelt et al. · Science · 2013 · 9.4K citations · Full text

, , +15

Improving CRISPR-Cas nuclease specificity using truncated guide RNAs

Yanfang Fu, Jeffry D. Sander, Deepak Reyon et al. · Nature Biotechnology · 2014 · 2K citations · Full text

, , +14

Analysis of off-target effects of CRISPR/Cas-derived RNA-guided endonucleases and nickases

Seung Woo Cho, Sojung Kim, Yongsub Kim et al. · Genome Research · 2013 · 1.4K citations · Full text

, , +14

CRISPRdirect: software for designing CRISPR/Cas guide RNA with reduced off-target sites

Yuki Naito, Kimihiro Hino, Hidemasa Bono et al. · Bioinformatics · 2014 · 1.4K citations · Full text

, , +15

Two distinct RNase activities of CRISPR-C2c2 enable guide-RNA processing and RNA detection

Alexandra East-Seletsky, Mitchell R. O’Connell, Spencer C. Knight et al. · Nature · 2016 · 1.2K citations

, , +9

1–5 of 178

Authors

1.1K

  1. JA
    Jennifer A. Doudna

    University of California, Berkeley, United States

    7 publications · 1.8K citations

    7

    h-index

  2. JC
    Jorge Cruz‐Reyes

    Texas A&M University, United States

    4 publications · 191 citations

    4

    h-index

  3. CL
    Chun Liang

    Miami University, United States

    3 publications · 139 citations

    3

    h-index

  4. WJ
    William J. Greenleaf

    Stanford University, United States

    3 publications · 281 citations

    3

    h-index

  5. CS
    Christina S. Leslie

    Memorial Sloan Kettering Cancer Center, United States

    3 publications · 88 citations

    3

    h-index

1–5 of 1.1K

Institutions

317

  1. Howard Hughes Medical Institute

    Chevy Chase, United States

    17 h-index

    50 publications

    14.7K citations

  2. University of California, Berkeley

    Berkeley, United States

    10 h-index

    37 publications

    13.3K citations

  3. Harvard University

    Cambridge, United States

    9 h-index

    31 publications

    75.8K citations

  4. Stanford University

    Stanford, United States

    8 h-index

    54 publications

    5.7K citations

  5. University of Chinese Academy of Sciences

    Beijing, China

    8 h-index

    28 publications

    4.1K citations

  6. University of California, San Francisco

    San Francisco, United States

    7 h-index

    33 publications

    7.9K citations

  7. Innovative Genomics Institute

    Berkeley, United States

    7 h-index

    11 publications

    1.9K citations

  8. Chinese Academy of Sciences

    Beijing, China

    7 h-index

    41 publications

    5.3K citations

1–8 of 317

Venues

  1. Nucleic Acids Research

    27 publications · 2.9K citations

    22

    h-index

  2. Nature Communications

    16 publications · 1.3K citations

    14

    h-index

  3. Genome biology

    10 publications · 2.1K citations

    10

    h-index

  4. RNA

    9 publications · 252 citations

    9

    h-index

  5. Nature Biotechnology

    8 publications · 3.8K citations

    8

    h-index

1–5