Concepedia

Fcrn Binding Engineering

FcRn Binding Engineering is a methodological framework within Fc engineering that specifically involves the rational modification of the neonatal Fc receptor (FcRn) binding interface to modulate the pharmacokinetic properties of therapeutic antibodies by enhancing their half-life and serum persistence.

50

Publications

3.8K

Citations

321

Authors

85

Institutions

Publications per year

2017–2026

18

Parents

Publications

50

Properties of Human IgG1s Engineered for Enhanced Binding to the Neonatal Fc Receptor (FcRn)

William F. Dall’Acqua, Peter A. Kiener, Herren Wu · Journal of Biological Chemistry · 2006 · 637 citations · Full text

, , +15

Increasing the Affinity of a Human IgG1 for the Neonatal Fc Receptor: Biological Consequences

William F. Dall’ Acqua, Robert M. Woods, E. Sally Ward et al. · The Journal of Immunology · 2002 · 367 citations

, , +13

Reduced elimination of IgG antibodies by engineering the variable region

Tomoyuki Igawa, Hiroyuki Tsunoda, Tatsuhiko Tachibana et al. · Protein Engineering Design and Selection · 2010 · 262 citations

, , +17

Extending Half-life by Indirect Targeting of the Neonatal Fc Receptor (FcRn) Using a Minimal Albumin Binding Domain

Jan Terje Andersen, Rikard Pehrson, Vladimir Tolmachev et al. · Journal of Biological Chemistry · 2010 · 171 citations · Full text

, , +17

Monoclonal Antibody Clearance

Amita Datta‐Mannan, Derrick R. Witcher, Ying Tang et al. · Journal of Biological Chemistry · 2006 · 163 citations · Full text

, , +17

1–5 of 50

Authors

321

  1. ES
    E. Sally Ward

    The University of Texas Southwestern Medical Center, United States

    5 publications · 724 citations

    5

    h-index

  2. YG
    Y. Gloria Meng

    Gene Therapy Laboratory, France

    4 publications · 295 citations

    4

    h-index

  3. KA
    Kenneth A. Howard

    Aarhus University, Denmark

    4 publications · 99 citations

    4

    h-index

  4. JT
    Jan Terje Andersen

    University of Oslo, Norway

    4 publications · 377 citations

    4

    h-index

  5. RD
    Rong Deng

    Sichuan University, China

    4 publications · 358 citations

    4

    h-index

1–5 of 321

Institutions

85

  1. The University of Texas Southwestern Medical Center

    Dallas, United States

    5 h-index

    23 publications

    2.3K citations

  2. Eli Lilly (United States)

    Indianapolis, United States

    4 h-index

    15 publications

    821 citations

  3. University of Oslo

    Oslo, Norway

    4 h-index

    16 publications

    1.1K citations

  4. Aarhus University

    Aarhus, Denmark

    4 h-index

    18 publications

    482 citations

  5. Chugai Pharma (United States)

    Berkeley Heights, United States

    3 h-index

    13 publications

    2.9K citations

  6. Fudan University

    Shanghai, China

    2 h-index

    4 publications

    92 citations

  7. Gene Therapy Laboratory

    Nantes, France

    2 h-index

    3 publications

    109 citations

  8. The University of Texas at Dallas

    Richardson, United States

    2 h-index

    2 publications

    185 citations

1–8 of 85

Venues

  1. mAbs

    10 publications · 548 citations

    10

    h-index

  2. Journal of Biological Chemistry

    JBC · 6 publications · 1.1K citations

    6

    h-index

  3. Molecular Immunology

    3 publications · 158 citations

    3

    h-index

  4. Drug Metabolism and Disposition

    2 publications · 168 citations

    2

    h-index

  5. Journal of Controlled Release

    2 publications · 76 citations

    2

    h-index

1–5