Concepedia

Fc Mutagenesis

Fc Mutagenesis is a targeted engineering methodology involving the systematic alteration of amino acid residues within the crystallizable fragment (Fc) region of an antibody to modulate its effector functions, stability, and pharmacokinetic properties while preserving structural integrity.

24

Publications

2.2K

Citations

186

Authors

55

Institutions

Publications per year

2017–2026

7

Parents

Publications

24

Novel human IgG1 and IgG4 Fc-engineered antibodies with completely abolished immune effector functions

Tilman Schlothauer, Sylvia Herter, Claudia Ferrara et al. · Protein Engineering Design and Selection · 2016 · 419 citations · Full text

, , +17

Increasing the Affinity of a Human IgG1 for the Neonatal Fc Receptor: Biological Consequences

William F. Dall’ Acqua, Robert M. Woods, E. Sally Ward et al. · The Journal of Immunology · 2002 · 367 citations

, , +13

Structural characterization of a human Fc fragment engineered for lack of effector functions

Vaheh Oganesyan, Changshou Gao, Lena Shirinian et al. · Acta Crystallographica Section D Biological Crystallography · 2008 · 197 citations · Full text

, , +15

Delineation of the amino acid residues involved in transcytosis and catabolism of mouse IgG1

Corneliu Medesan, Diana Matesoi, Caius G. Radu et al. · The Journal of Immunology · 1997 · 172 citations

, , +14

Rationale-Based Engineering of a Potent Long-Acting FGF21 Analog for the Treatment of Type 2 Diabetes

Randy Hecht, Yuesheng Li, Jeonghoon Sun et al. · PLoS ONE · 2012 · 166 citations · Full text

, , +16

1–5 of 24

Authors

186

  1. ES
    E. Sally Ward

    The University of Texas Southwestern Medical Center, United States

    3 publications · 681 citations

    3

    h-index

  2. HW
    Herren Wu

    AstraZeneca (Germany), Germany

    3 publications · 651 citations

    3

    h-index

  3. VO
    Vaheh Oganesyan

    AstraZeneca (Germany), Germany

    2 publications · 284 citations

    2

    h-index

  4. PM
    P. Mark Hogarth

    The University of Melbourne, Australia

    2 publications · 67 citations

    2

    h-index

  5. VG
    Victor Gheţie

    The University of Texas Southwestern Medical Center, United States

    2 publications · 314 citations

    2

    h-index

1–5 of 186

Institutions

55

  1. The University of Texas Southwestern Medical Center

    Dallas, United States

    3 h-index

    10 publications

    1.8K citations

  2. Austin Health

    Melbourne, Australia

    2 h-index

    8 publications

    239 citations

  3. Burnet Institute

    Melbourne, Australia

    2 h-index

    6 publications

    203 citations

  4. Janssen (United States)

    Hopewell, United States

    2 h-index

    9 publications

    272 citations

  5. Amgen (United States)

    Thousand Oaks, United States

    2 h-index

    24 publications

    3.6K citations

  6. University of Veterinary Medicine Vienna

    Vienna, Austria

    1 h-index

    2 publications

    30 citations

  7. Carterra (United States)

    Salt Lake City, United States

    1 h-index

    1 publications

    30 citations

  8. Tokyo Institute of Technology

    Tokyo, Japan

    1 h-index

    2 publications

    60 citations

1–8 of 55

Venues

  1. The Journal of Immunology

    JI · 4 publications · 670 citations

    4

    h-index

  2. Protein Engineering Design and Selection

    PEDS · 3 publications · 580 citations

    3

    h-index

  3. mAbs

    3 publications · 81 citations

    3

    h-index

  4. Frontiers in Immunology

    1 publications · 15 citations

    1

    h-index

  5. 1

    h-index

1–5