Concepedia

Evolutionary Constraint Analysis

Evolutionary Constraint Analysis is a computational framework in population genomics that identifies genomic elements under purifying selection by quantifying the depletion of genetic variation relative to neutral expectations across evolutionary timescales.

157

Publications

15.5K

Citations

1.2K

Authors

521

Institutions

Publications per year

2017–2026

55

Parents

Publications

157

Distribution and intensity of constraint in mammalian genomic sequence

Gregory M. Cooper, Eric A. Stone, George Asimenos et al. · Genome Research · 2005 · 1.4K citations · Full text

, , +15

A genomic mutational constraint map using variation in 76,156 human genomes

Siwei Chen, Laurent C. Francioli, Julia K. Goodrich et al. · Nature · 2023 · 1.3K citations · Full text

, , +14

A high-resolution map of human evolutionary constraint using 29 mammals

Kerstin Lindblad‐Toh, Manuel Garber, Or Zuk et al. · Nature · 2011 · 1.2K citations · Full text

, , +17

Transposable Elements Are Major Contributors to the Origin, Diversification, and Regulation of Vertebrate Long Noncoding RNAs

Aurélie Kapusta, Zev Kronenberg, Vincent J. Lynch et al. · PLoS Genetics · 2013 · 724 citations · Full text

, , +14

Integrative annotation of chromatin elements from ENCODE data

Michael M. Hoffman, Jason Ernst, Steven P. Wilder et al. · Nucleic Acids Research · 2012 · 621 citations · Full text

, , +13

1–5 of 157

Authors

1.2K

  1. RC
    Ross C. Hardison

    Pennsylvania State University, United States

    7 publications · 1.4K citations

    7

    h-index

  2. WM
    Webb Miller

    Pennsylvania State University, United States

    6 publications · 690 citations

    6

    h-index

  3. KL
    Kerstin Lindblad‐Toh

    Broad Institute, United States

    7 publications · 2.2K citations

    6

    h-index

  4. MK
    Manolis Kellis

    Broad Institute, United States

    5 publications · 881 citations

    5

    h-index

  5. FC
    Francesca Chiaromonte

    Pennsylvania State University, United States

    5 publications · 518 citations

    5

    h-index

1–5 of 1.2K

Institutions

521

  1. Stanford University

    Stanford, United States

    15 h-index

    56 publications

    10.5K citations

  2. Broad Institute

    Cambridge, United States

    13 h-index

    184 publications

    175.1K citations

  3. Pennsylvania State University

    State College, United States

    11 h-index

    64 publications

    9.8K citations

  4. National Institutes of Health

    Bethesda, United States

    9 h-index

    27 publications

    7.1K citations

  5. Howard Hughes Medical Institute

    Chevy Chase, United States

    9 h-index

    27 publications

    6.5K citations

  6. National Human Genome Research Institute

    Bethesda, United States

    8 h-index

    28 publications

    7.5K citations

  7. Harvard University

    Cambridge, United States

    7 h-index

    32 publications

    26.2K citations

  8. Universitat Pompeu Fabra

    Barcelona, Spain

    6 h-index

    27 publications

    3.7K citations

1–8 of 521

Venues

  1. Genome Research

    GR · 12 publications · 2.7K citations

    12

    h-index

  2. Molecular Biology and Evolution

    MBE · 14 publications · 841 citations

    12

    h-index

  3. bioRxiv (Cold Spring Harbor Laboratory)

    Repository · 8 publications · 154 citations

    8

    h-index

  4. Evolution

    7 publications · 661 citations

    7

    h-index

  5. PLoS ONE

    7 publications · 209 citations

    7

    h-index

1–5