A genomic mutational constraint map using variation in 76,156 human genomes

Siwei Chen, Laurent C. Francioli, Julia K. Goodrich, +232

Nature

MedicineGeneticsEvolutionary BiologyNatural SciencesGenome Analysis +6

Inhibition of histone deacetylase 1 (HDAC1) and HDAC2 enhances CRISPR/Cas9 genome editing

Bin Liu, Siwei Chen, Anouk La Rose, +7

Nucleic Acids Research

Histone ModificationsChromatinChromatin CompactionHistone ModifiersChromatin Remodeling +13

A genome-wide mutational constraint map quantified from variation in 76,156 human genomes

Siwei Chen, Laurent C. Francioli, Julia K. Goodrich, +42

Gene Constraint MetricsGeneticsGenetic EpidemiologyNatural SelectionGenomics +21

Defining the Independence of the Liver Circadian Clock

Kevin B. Koronowski, Kenichiro Kinouchi, Patrick-Simon Welz, +11

Cell

SleepAlertnessHepatologyHealth SciencesMedicine +9

Time of Exercise Specifies the Impact on Muscle Metabolic Pathways and Systemic Energy Homeostasis

Shogo Sato, A. Basse, Milena Schönke, +10

Cell Metabolism

Physical ActivityKinesiologyExercise SpecifiesExerciseExercise Physiology +9

Atlas of exercise metabolism reveals time-dependent signatures of metabolic homeostasis

Shogo Sato, Kenneth A. Dyar, Jonas T. Treebak, +19

Cell Metabolism

Physical ActivityHomeostatic MechanismMetabolic SyndromeBody CompositionKinesiology +16

Epigenetic regulation of the circadian gene Per1 contributes to age-related changes in hippocampal memory

Janine L. Kwapis, Yasaman Alaghband, Enikö A. Kramár, +14

Nature Communications

RIPK3/MLKL-Mediated Neuronal Necroptosis Modulates the M1/M2 Polarization of Microglia/Macrophages in the Ischemic Cortex

Jiping Yang, Youyi Zhao, Li Zhang, +10

Cerebral Cortex

Integration of feeding behavior by the liver circadian clock reveals network dependency of metabolic rhythms

Carolina M. Greco, Kevin B. Koronowski, Jacob G. Smith, +26

Science Advances

NutritionMetabolic RhythmsHomeostatic MechanismFood IntakeObesity +21

Higher systemic immune-inflammation index and systemic inflammation response index levels are associated with stroke prevalence in the asthmatic population: a cross-sectional analysis of the NHANES 1999-2018

Wenke Cheng, Xiancong Bu, Chunhua Xu, +5

Frontiers in Immunology