Epitope spreading is an immunological phenomenon characterized by the expansion of immune responses from an initial target epitope to additional epitopes on the same or different self-antigens, thereby contributing to the progression and diversification of autoimmune reactions.
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Spreading of T-cell autoimmunity to cryptic determinants of an autoantigen
Paul Lehmann, Thomas G. Forsthuber, Alexander Miller et al. · Nature · 1992 · 1.2K citations
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Northwestern University
Evanston, United States
10 h-index
41 publications
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Cleveland Clinic
Cleveland, United States
7 h-index
31 publications
2.6K citations
University of Virginia
Charlottesville, United States
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682 citations
University of Virginia Health System
Charlottesville, United States
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University of Oxford
Oxford, United Kingdom
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Stanford, United States
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University of Oklahoma Health Sciences Center
Oklahoma City, United States
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5 publications · 1.5K citations
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4 publications · 282 citations
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