Concepedia

Enzyme Target Validation

Enzyme Target Validation is a systematic experimental and computational process within biochemical and pharmaceutical research that confirms the causal relationship between a specific enzyme and a disease phenotype, thereby establishing its suitability as a therapeutic intervention point.

33

Publications

1.7K

Citations

267

Authors

102

Institutions

Publications per year

2017–2026

15

Parents

Publications

33

Comprehensive characterization of the Published Kinase Inhibitor Set

Jonathan M. Elkins, Vita Fedele, M. Szklarz et al. · Nature Biotechnology · 2015 · 350 citations

, , +13

Cancer-related issues of CD147.

Ulrich H. Weidle, Werner Scheuer, Daniela Eggle et al. · PubMed · 2010 · 170 citations

, , +17

Peptide Deformylase as an Antibacterial Drug Target: Target Validation and Resistance Development

Christian Apfel, Hans H. Locher, Stefan Evers et al. · Antimicrobial Agents and Chemotherapy · 2001 · 126 citations · Full text

, , +17

Metabolic and Bactericidal Effects of Targeted Suppression of NadD and NadE Enzymes in Mycobacteria

Irina A. Rodionova, Brian M. Schuster, Kristine M. Guinn et al. · mBio · 2014 · 84 citations · Full text

, , +17

Isoform-selective NADPH oxidase inhibitor panel for pharmacological target validation

Vu Thao-Vi Dao, Mahmoud H. Elbatreek, Sebastian Altenhöfer et al. · Free Radical Biology and Medicine · 2019 · 75 citations · Full text

, , +14

1–5 of 33

Authors

267

  1. XH
    Xun Huang

    Chinese Academy of Sciences, China

    1 publications · 26 citations

    1

    h-index

  2. KL
    Karen Lackey

    Research Triangle Park Foundation, United States

    1 publications · 350 citations

    1

    h-index

  3. GM
    Gerardo M. Casañola‐Martín

    Universitat de València, Spain

    1 publications · 18 citations

    1

    h-index

  4. AM
    Angamba Meetei Potshangbam

    Manipur University, India

    1 publications · 14 citations

    1

    h-index

  5. CT
    Christopher T. Neullens

    Maastricht University, Netherlands

    1 publications · 75 citations

    1

    h-index

1–5 of 267

Institutions

102

  1. Universidad Nacional Autónoma de México

    Mexico City, Mexico

    3 h-index

    8 publications

    332 citations

  2. Harvard University

    Cambridge, United States

    3 h-index

    10 publications

    630 citations

  3. Goethe University Frankfurt

    Frankfurt am Main, Germany

    2 h-index

    2 publications

    425 citations

  4. Louisiana State University

    Baton Rouge, United States

    2 h-index

    3 publications

    198 citations

  5. University of Georgia

    Athens, United States

    2 h-index

    5 publications

    226 citations

  6. Kasetsart University

    Bangkok, Thailand

    1 h-index

    2 publications

    52 citations

  7. Universidade do Porto

    Porto, Portugal

    1 h-index

    1 publications

    48 citations

  8. Zagazig University

    Zagazig, Egypt

    1 h-index

    1 publications

    75 citations

1–8 of 102

Venues

  1. Journal of Medicinal Chemistry

    2 publications · 44 citations

    2

    h-index

  2. Current Molecular Medicine

    1 publications · 32 citations

    1

    h-index

  3. Nature Biotechnology

    1 publications · 350 citations

    1

    h-index

  4. Pesticide Biochemistry and Physiology

    PBP · 1 publications · 20 citations

    1

    h-index

  5. Biomolecules

    1 publications · 13 citations

    1

    h-index

1–5