Hans H. Locher

Chimeric peptidomimetic antibiotics against Gram-negative bacteria

Anatol Luther, Matthias Urfer, Michael Zahn et al. · Nature · 2019 · 307 citations

Gram-negative Bacteriology, Antibiotics, Antibiotic Adjuvant +7

A single amino acid substitution in Staphylococcus aureus dihydrofolate reductase determines trimethoprim resistance 1 1 Edited by T.Richmond

Glenn E. Dale, Clemens Broger, Allan D' Arcy et al. · Journal of Molecular Biology · 1997 · 177 citations

Antimicrobial Resistance Gene, Biochemistry, Natural Sciences +8

Peptide Deformylase as an Antibacterial Drug Target: Target Validation and Resistance Development

Christian Apfel, Hans H. Locher, Stefan Evers et al. · Antimicrobial Agents and Chemotherapy · 2001 · 126 citations · Full text

Bioorganic Chemistry, Peptide Engineering, Antibacterial Activity +19

Hydroxamic Acid Derivatives as Potent Peptide Deformylase Inhibitors and Antibacterial Agents

Christian Apfel, David W. Banner, Daniel Bur et al. · Journal of Medicinal Chemistry · 2000 · 111 citations · Full text

Antibacterial Agents, Antimicrobial Chemotherapy, Chemical Biology +19

<i>In Vitro</i>and<i>In Vivo</i>Antibacterial Evaluation of Cadazolid, a New Antibiotic for Treatment of Clostridium difficile Infections

Hans H. Locher, Peter Seiler, Xinhua Chen et al. · Antimicrobial Agents and Chemotherapy · 2013 · 89 citations · Full text