Concepedia

Author

Christian Apfel

Roche (Switzerland)

Also Known As

B. Jacobsen, C Apfel, C. Apfel, C. M. Apfel, C.M. Apfel, Christian Apfel, Christian M Apfel, Christian M. Apfel

37

Publications

1.4K

Citations

14

H-Index

40

Concepts

All Affiliations

Roche (Switzerland)
CA

About

Christian Apfel is an author at Roche (Switzerland) specializing in medicine, biochemistry, and pharmacology.

Top Concepts

#ConceptH-IndexPublicationsCitations

1

Medicine

10

10

766

2

Biochemistry

7

7

465

3

Natural Sciences

6

6

446

4

Cell Biology

3

3

394

5

Engineering

1

1

29

Christian Apfel

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16

Publications

1.3K

Citations

14

H-Index

YearCitations

A retinoic acid receptor alpha antagonist selectively counteracts retinoic acid effects.

Christian Apfel, F.W. Bauer, Marco Crettaz,

Proceedings of the National Academy of Sciences

1992

258

Use of Genomics To Identify Bacterial Undecaprenyl Pyrophosphate Synthetase: Cloning, Expression, and Characterization of the Essential <i>uppS</i> Gene

Christian Apfel, Béla Takács, Michael Fountoulakis,

Journal of Bacteriology

1999

190

Phytanic Acid is a Retinoid X Receptor Ligand

Peter K. LeMotte, Siegfried Keidel, Christian Apfel

European Journal of Biochemistry

1996

151

Peptide Deformylase as an Antibacterial Drug Target: Target Validation and Resistance Development

Christian Apfel, Hans H. Locher, Stefan Evers,

Antimicrobial Agents and Chemotherapy

2001

126

Different agonist- and antagonist-induced conformational changes in retinoic acid receptors analyzed by protease mapping.

Siegfried Keidel, Peter K. LeMotte, Christian Apfel

Molecular and Cellular Biology

1994

125

Hydroxamic Acid Derivatives as Potent Peptide Deformylase Inhibitors and Antibacterial Agents

Christian Apfel, David W. Banner, Daniel Bur,

Journal of Medicinal Chemistry

2000

111

Enhancement of HL-60 Differentiation by a New Class of Retinoids with Selective Activity on Retinoid X Receptor

Christian Apfel, Markus Kamber, Michael Klaus,

Journal of Biological Chemistry

1995

91

Evaluation of a High-Throughput Fluorescence Assay Method for hERG Potassium Channel Inhibition

Arnulf Dorn, Francis Hermann, Andreas Ebneth,

SLAS DISCOVERY

2005

66

RARα antagonist RO 41-5253 inhibits proliferation and induces apoptosis in breast-cancer cell lines

Salvatore Toma, L Isnardi, P Raffo,

International Journal of Cancer

1998

47

2-(2-Oxo-1,4-dihydro-2<i>H</i>-quinazolin-3-yl)- and 2-(2,2-Dioxo-1,4-dihydro-2<i>H</i>-2λ<sup>6</sup>-benzo[1,2,6]thiadiazin-3-yl)-<i>N</i>-hydroxy-acetamides as Potent and Selective Peptide Deformylase Inhibitors

Christian Apfel, David W. Banner, Daniel Bur,

Journal of Medicinal Chemistry

2001

40

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