Fragment-Based Drug Discovery of 2-Thiazolidinones as Inhibitors of the Histone Reader BRD4 Bromodomain

Lele Zhao, Danyan Cao, Tiantian Chen, +13

Journal of Medicinal Chemistry

Molecular DockingFragment 8Medicinal ChemistryFragment-based Drug DiscoveryIntegrated Lead Optimization +12

Fragment-Based Drug Discovery of 2-Thiazolidinones as BRD4 Inhibitors: 2. Structure-Based Optimization

Lele Zhao, Ying-Qing Wang, Danyan Cao, +16

Journal of Medicinal Chemistry

Structure-Based Discovery and Development of a Series of Potent and Selective Bromodomain and Extra-Terminal Protein Inhibitors

Jianping Hu, Changqing Tian, Mohammadali Soleimani Damaneh, +16

Journal of Medicinal Chemistry

Structure-Based Discovery of Potent CARM1 Inhibitors for Solid Tumor and Cancer Immunology Therapy

Zhuqing Zhang, Zuhao Guo, Xiaowei Xu, +15

Journal of Medicinal Chemistry

Discovery of a series of dihydroquinoxalin-2(1H)-ones as selective BET inhibitors from a dual PLK1-BRD4 inhibitor

Jianping Hu, Ying-Qing Wang, Yanlian Li, +10

European Journal of Medicinal Chemistry

Medicinal ChemistryBioorganic ChemistryBiochemistryDual Plk1-brd4 InhibitorNatural Sciences +10

Fragment-based drug discovery of triazole inhibitors to block PDEδ-RAS protein-protein interaction

Danqi Chen, Yuehong Chen, Fulin Lian, +12

European Journal of Medicinal Chemistry

Fragment-based Drug DiscoveryDrug TargetBiochemistryPdeδ-ras Protein-protein InteractionMedicine +9

Design and Synthesis of Potent, Selective Inhibitors of Protein Arginine Methyltransferase 4 against Acute Myeloid Leukemia

Zuhao Guo, Zhuqing Zhang, Hong Yang, +15

Journal of Medicinal Chemistry

Arginine MethyltransferaseDrug TargetBiochemistryMedicineAcute Myeloid Leukemia +12

Multi-substituted 8-aminoimidazo[1,2-a]pyrazines by Groebke–Blackburn–Bienaymé reaction and their Hsp90 inhibitory activity

Jing Ren, Min Yang, Hong‐Chun Liu, +9

Organic & Biomolecular Chemistry

Molecular PharmacologyMedicinal ChemistryHsp90 Inhibitory ActivityYttrium Triflate CatalystPharmaceutical Chemistry +10

Structure-Based Discovery of a Series of NSD2-PWWP1 Inhibitors

Na Li, Hong Yang, Ke Liu, +16

Journal of Medicinal Chemistry

Identification of a new series of potent diphenol HSP90 inhibitors by fragment merging and structure-based optimization

Jing Ren, Jian Li, Yueqin Wang, +12

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryDrug TargetBiochemistryMedicineNatural Sciences +9