Concepedia

Enantioselectivity Engineering

Enantioselectivity Engineering is a methodological framework within directed evolution of enzymes that specifically tailors catalytic activity to preferentially produce one enantiomer over another by systematically modifying enzyme structure and function.

105

Publications

5.1K

Citations

520

Authors

155

Institutions

Publications per year

2017–2026

34

Parents

Publications

105

Development of an Amine Dehydrogenase for Synthesis of Chiral Amines

Michael J. Abrahamson, Eduardo Vázquez‐Figueroa, Nicholas B. Woodall et al. · Angewandte Chemie International Edition · 2012 · 273 citations

, , +10

Creation of a Productive, Highly Enantioselective Nitrilase through Gene Site Saturation Mutagenesis (GSSM)

Grace DeSantis, Kelvin K. L. Wong, Bob Farwell et al. · Journal of the American Chemical Society · 2003 · 258 citations

, , +16

Enantioselective Enzyme-Catalyzed Aziridination Enabled by Active-Site Evolution of a Cytochrome P450

Christopher C. Farwell, Ruijie K. Zhang, John A. McIntosh et al. · ACS Central Science · 2015 · 185 citations · Full text

, , +17

Modulation of the enantioselectivity of lipases via controlled immobilization and medium engineering: hydrolytic resolution of mandelic acid esters

José M. Palomo, Gloria Fernández‐Lorente, César Mateo et al. · Enzyme and Microbial Technology · 2002 · 178 citations

, , +13

Ionic Liquid-Coated Enzyme for Biocatalysis in Organic Solvent

Jae Kwan Lee, Mahn‐Joo Kim · The Journal of Organic Chemistry · 2002 · 171 citations

, , +17

1–5 of 105

Authors

520

  1. GJ
    Gerrit J. Poelarends

    University of Groningen, Netherlands

    4 publications · 179 citations

    4

    h-index

  2. ST
    Shau‐Wei Tsai

    National Cheng Kung University, Taiwan

    3 publications · 88 citations

    3

    h-index

  3. DW
    Dongzhi Wei

    East China University of Science and Technology, China

    3 publications · 87 citations

    3

    h-index

  4. AT
    A.M.W.H. Thunnissen

    University of Groningen, Netherlands

    3 publications · 154 citations

    3

    h-index

  5. JM
    José M. Guisán

    Instituto de Catálisis y Petroleoquímica, Spain

    3 publications · 235 citations

    3

    h-index

1–5 of 520

Institutions

155

  1. Zhejiang University of Technology

    Hangzhou, China

    7 h-index

    45 publications

    1.1K citations

  2. University of Groningen

    Groningen, The Netherlands

    5 h-index

    33 publications

    1.8K citations

  3. Jiangnan University

    Wuxi, China

    5 h-index

    24 publications

    767 citations

  4. East China University of Science and Technology

    Shanghai, China

    4 h-index

    24 publications

    812 citations

  5. Consejo Superior de Investigaciones Científicas

    Madrid, Spain

    3 h-index

    22 publications

    756 citations

  6. Chinese Academy of Sciences

    Beijing, China

    3 h-index

    10 publications

    326 citations

  7. Instituto de Catálisis y Petroleoquímica

    Madrid, Spain

    3 h-index

    10 publications

    306 citations

  8. National Cheng Kung University

    Tainan City, Taiwan

    3 h-index

    6 publications

    184 citations

1–8 of 155

Venues

  1. Tetrahedron Asymmetry

    7 publications · 289 citations

    7

    h-index

  2. Angewandte Chemie International Edition

    7 publications · 501 citations

    7

    h-index

  3. The Journal of Organic Chemistry

    JOC · 6 publications · 535 citations

    6

    h-index

  4. Applied and Environmental Microbiology

    AEM · 5 publications · 308 citations

    5

    h-index

  5. ACS Catalysis

    5 publications · 250 citations

    5

    h-index

1–5