Concepedia

Effector Caspase Activation

Effector Caspase Activation is a biochemical mechanism—in the genus of cellular regulatory processes—specifically defined as the proteolytic cleavage and subsequent activation of effector caspases (such as caspase-3, -6, and -7) initiated by the apoptosome, which distinguishes it from other caspase activation pathways by its dependence on cytochrome c, Apaf-1, and initiator caspase-9-mediated signaling during intrinsic apoptosis.

336

Publications

28.4K

Citations

1.9K

Authors

578

Institutions

Publications per year

2017–2026

41

Parents

Publications

336

A Combinatorial Approach Defines Specificities of Members of the Caspase Family and Granzyme B

Nancy A. Thornberry, Thomas A. Rano, Erin P. Peterson et al. · Journal of Biological Chemistry · 1997 · 2.1K citations · Full text

, , +14

Cytoplasmic LPS Activates Caspase-11: Implications in TLR4-Independent Endotoxic Shock

Jon A. Hagar, Daniel A. Powell, Youssef Aachoui et al. · Science · 2013 · 1.2K citations · Full text

, , +14

Caspases 3 and 7: Key Mediators of Mitochondrial Events of Apoptosis

Saquib A. Lakhani, Ali J. Masud, Keisuke Kuida et al. · Science · 2006 · 1.2K citations

, , +17

Distinct Caspase Cascades Are Initiated in Receptor-mediated and Chemical-induced Apoptosis

Xiaoming Sun, Marion MacFarlane, Jianguo Zhuang et al. · Journal of Biological Chemistry · 1999 · 824 citations · Full text

, , +17

Toxic bile salts induce rodent hepatocyte apoptosis via direct activation of Fas

William A. Faubion, Maria Eugenia Guicciardi, Hideyuki Miyoshi et al. · Journal of Clinical Investigation · 1999 · 539 citations · Full text

, , +17

1–5 of 336

Authors

1.9K

  1. GM
    Gerald M. Cohen

    University of Leicester, United Kingdom

    6 publications · 2K citations

    6

    h-index

  2. KC
    Kelvin Cain

    MRC Toxicology Unit, United Kingdom

    5 publications · 944 citations

    5

    h-index

  3. DP
    David Piwnica‐Worms

    Mallinckrodt (United States), United States

    5 publications · 420 citations

    5

    h-index

  4. SH
    Scott H. Kaufmann

    Mayo Clinic, United States

    5 publications · 963 citations

    5

    h-index

  5. MR
    Markus Rehm

    Ludwig-Maximilians-Universität München, Germany

    5 publications · 634 citations

    5

    h-index

1–5 of 1.9K

Institutions

578

  1. Inserm

    Paris, France

    11 h-index

    55 publications

    3.7K citations

  2. University of Leicester

    Leicester, United Kingdom

    9 h-index

    36 publications

    9.8K citations

  3. University of Münster

    Münster, Germany

    7 h-index

    31 publications

    2.8K citations

  4. The University of Texas MD Anderson Cancer Center

    Houston, United States

    7 h-index

    49 publications

    4.3K citations

  5. Centre National de la Recherche Scientifique

    Paris, France

    7 h-index

    21 publications

    2.3K citations

  6. Sanford Burnham Prebys Medical Discovery Institute

    La Jolla, United States

    6 h-index

    34 publications

    3.4K citations

  7. University of Miami

    Coral Gables, United States

    6 h-index

    24 publications

    2.1K citations

  8. Technical University of Munich

    Munich, Germany

    6 h-index

    24 publications

    1.8K citations

1–8 of 578

Venues

  1. Journal of Biological Chemistry

    JBC · 45 publications · 8.5K citations

    41

    h-index

  2. PubMed

    Repository · 12 publications · 474 citations

    12

    h-index

  3. PLoS ONE

    12 publications · 335 citations

    12

    h-index

  4. The Journal of Immunology

    JI · 7 publications · 381 citations

    7

    h-index

  5. Fish & Shellfish Immunology

    7 publications · 177 citations

    7

    h-index

1–5