Downstream Processing

Downstream processing is the bioprocessing stage comprising unit operations for the recovery, purification, isolation, and concentration of biosynthetic pharmaceutical products from harvested cell cultures or fermentation broth.

4.4K

Publications

230.5K

Citations

16.5K

Authors

3.1K

Institutions

Publications per year

2017–2026

1.4K

Parents

Pharmaceutical Biotechnology

Children

Affinity ChromatographyBioproduct RecoveryBuffer ExchangeCell DisruptionCell HarvestingCell SeparationChromatographic PurificationEndotoxin RemovalHydrophobic Interaction ChromatographyIon-exchange Chromatography

Publications

4.4K

Recovery of microalgal biomass and metabolites: process options and economics

E. Molina Grima, El‐Hassan Belarbi, F.G. Acién et al. · Biotechnology Advances · 2002 · 2.2K citations

Life Sciences, Biotechnology, Environmental Engineering +14

Biodiesel processing and production

Jon Van Gerpen · Fuel Processing Technology · 2005 · 2.2K citations

Engineering, Biotechnology, Chemical Engineering +12

Green processing using ionic liquids and CO2

Lynnette A. Blanchard, Dan Hâncu, Eric J. Beckman et al. · Nature · 1999 · 2K citations

Natural Sciences, Chemical Engineering, Chemistry +10

Progress in bioethanol processing

Mustafa Balat, Havva Balat, Cahide Öz · Progress in Energy and Combustion Science · 2008 · 1.5K citations

Life Sciences, Bioengineering, Biotechnology +11

Possible methods for biodiesel production

J.M. Marchetti, V.U. Miguel, A.F. Errazu · Renewable and Sustainable Energy Reviews · 2005 · 1.5K citations

Engineering, Biotechnology, Chemical Engineering +14

1–5 of 4.4K

Authors

16.5K

YN
Yonghao Ni
University of New Brunswick, Canada
30 publications · 1.6K citations
23
h-index
GZ
Guido Zacchi
Lund University, Sweden
15 publications · 1.8K citations
15
h-index
PF
Pedram Fatehi
Lakehead University, Canada
15 publications · 801 citations
15
h-index
BE
Bruce E. Dale
Michigan State University, United States
14 publications · 1.9K citations
14
h-index
MÂ
M. Ângela A. Meireles
Universidade Estadual de Campinas (UNICAMP), Brazil
14 publications · 1.4K citations
14
h-index

1–5 of 16.5K

Institutions

3.1K

1–8 of 3.1K

Venues

Bioresource Technology
279 publications · 21.5K citations
82
h-index
Journal of Membrane Science
81 publications · 5.6K citations
43
h-index
Separation and Purification Technology
124 publications · 5.1K citations
41
h-index
The Journal of Supercritical Fluids
77 publications · 4.2K citations
41
h-index
Water Research
71 publications · 4.6K citations
39
h-index

1–5

See also Downstream Processing
Core Methods	Liquid Chromatography Filtrations Cell Disruption Tangential Flow Filtration Hydrophobic Interaction Chromatography Solid-liquid Separation Virus Inactivation Mechanisms Protein A Chromatography Cation-exchange Chromatography Anion Chromatography Immobilized Metal Affinity Chromatography Ultrafiltration Diafiltration Static Membrane Filtration Crystallization Washing Drying
Process Stages	Solid-liquid Separation Virus Inactivation Mechanisms Polishing Ultrafiltration Formulation Science
Process Challenges	Process Scale-up Process Variation Knowledge Transfer Capacity
Separation Principles	Chromatography Filtrations Distillation Reactive Distillation Azeotropic Distillation Extractions Surface Adsorption Ionic Interactions Ligand Binding Size Exclusion Decantation Flash Separation Microfiltration Protein A Chromatography Cation-exchange Chromatography Anion Chromatography Ultrafiltration
Product Types	Monoclonal Antibodies Biologic Therapeutics