Concepedia

Disulfide Linkers

Disulfide Linkers is a type of cleavable chemical linker that contains a disulfide bond (-S-S-) enabling controlled release of payloads under reductive conditions, distinguishing it from non-cleavable or other stimuli-responsive linkers in targeted conjugation strategies.

1.2K

Publications

65K

Citations

5.8K

Authors

1.3K

Institutions

Publications per year

2017–2026

211

Parents

Publications

1.2K

Targeting HER2-Positive Breast Cancer with Trastuzumab-DM1, an Antibody–Cytotoxic Drug Conjugate

Gail D. Lewis Phillips, Guangmin Li, Debra L. Dugger et al. · Cancer Research · 2008 · 1.7K citations

, , +17

Cystine transporter regulation of pentose phosphate pathway dependency and disulfide stress exposes a targetable metabolic vulnerability in cancer

Xiaoguang Liu, Kellen Olszewski, Yilei Zhang et al. · Nature Cell Biology · 2020 · 595 citations · Full text

, , +17

A model for the structure of chromatin in mammalian sperm.

Rod Balhorn · The Journal of Cell Biology · 1982 · 573 citations · Full text

, , +17

Site-directed ligand discovery

Daniel A. Erlanson, Andrew C. Braisted, D.R. Raphael et al. · Proceedings of the National Academy of Sciences · 2000 · 466 citations

, , +17

Platelet plasma membrane glycoproteins. Evidence for the presence of nonequivalent disulfide bonds using nonreduced-reduced two-dimensional gel electrophoresis.

David R. Phillips, Patricia Poh Agin · Journal of Biological Chemistry · 1977 · 439 citations · Full text

, , +14

1–5 of 1.2K

Authors

5.8K

  1. DJ
    David J. Craik

    The University of Queensland, Australia

    12 publications · 1.3K citations

    12

    h-index

  2. WS
    Wei‐Chiang Shen

    University of Southern California, United States

    6 publications · 183 citations

    6

    h-index

  3. TH
    Thomas H. Pillow

    WuXi AppTec (China), China

    6 publications · 343 citations

    6

    h-index

  4. RJ
    Richard J. Clark

    The University of Queensland, Australia

    6 publications · 738 citations

    6

    h-index

  5. CW
    Chuanliu Wu

    Xiamen University, China

    5 publications · 180 citations

    5

    h-index

1–5 of 5.8K

Institutions

1.3K

  1. Centre National de la Recherche Scientifique

    Paris, France

    23 h-index

    199 publications

    8.9K citations

  2. National Institutes of Health

    Bethesda, United States

    20 h-index

    75 publications

    7.1K citations

  3. Harvard University

    Cambridge, United States

    17 h-index

    60 publications

    3.7K citations

  4. Chinese Academy of Sciences

    Beijing, China

    16 h-index

    70 publications

    3K citations

  5. The University of Queensland

    Brisbane, Australia

    15 h-index

    66 publications

    7.7K citations

  6. Inserm

    Paris, France

    14 h-index

    48 publications

    2.1K citations

  7. University of California, Los Angeles

    Los Angeles, United States

    14 h-index

    55 publications

    3.1K citations

  8. Massachusetts Institute of Technology

    Cambridge, United States

    13 h-index

    47 publications

    3.3K citations

1–8 of 1.3K

Venues

  1. Journal of Biological Chemistry

    JBC · 141 publications · 10K citations

    61

    h-index

  2. Proceedings of the National Academy of Sciences

    PNAS · 41 publications · 4.7K citations

    38

    h-index

  3. Biochemistry

    56 publications · 2.4K citations

    30

    h-index

  4. Journal of the American Chemical Society

    JACS · 24 publications · 2.3K citations

    22

    h-index

  5. FEBS Letters

    23 publications · 1K citations

    18

    h-index

1–5