Concepedia

Combination Therapy Repurposing

Combination Therapy Repurposing is a drug repurposing strategy that involves the systematic identification and validation of new therapeutic uses for existing drugs in combination regimens, distinguished from single-agent repurposing by its focus on synergistic or additive interactions between approved or investigational agents to enhance efficacy, overcome resistance, or reduce toxicity in novel disease contexts.

61

Publications

4.3K

Citations

360

Authors

186

Institutions

Publications per year

2017–2026

22

Parents

Children

Publications

61

The problem of synergism and antagonism of combined drugs.

S. Loewe · PubMed · 1953 · 984 citations

, , +9

First-line rituximab combined with short-term prednisone versus prednisone alone for the treatment of pemphigus (Ritux 3): a prospective, multicentre, parallel-group, open-label randomised trial

P. Joly, Maud Maho‐Vaillant, C. Prost‐Squarcioni et al. · The Lancet · 2017 · 596 citations

, , +9

Systems biology and combination therapy in the quest for clinical efficacy

Jonathan B. Fitzgerald, Birgit Schoeberl, Ulrik B. Nielsen et al. · Nature Chemical Biology · 2006 · 583 citations

, , +16

Systematic exploration of synergistic drug pairs

Murat Cokol, Hon Nian Chua, Murat Taşan et al. · Molecular Systems Biology · 2011 · 327 citations · Full text

, , +14

Drug repurposing strategies for COVID-19

Suranga L Senanayake · Future Drug Discovery · 2020 · 152 citations · Full text

, , +12

1–5 of 61

Authors

360

  1. EG
    E. G. V. Evans

    University of Leeds, United Kingdom

    3 publications · 101 citations

    3

    h-index

  2. DC
    Dong Chen

    Mayo Clinic, United States

    1 publications · 40 citations

    1

    h-index

  3. AB
    Anastasia Baryshnikova

    University of Toronto, Canada

    1 publications · 327 citations

    1

    h-index

  4. CJ
    Chao Ji

    First Affiliated Hospital of Fujian Medical University, China

    1 publications · 47 citations

    1

    h-index

  5. FL
    Francesco Lo‐Coco

    University of Rome Tor Vergata, Italy

    1 publications · 44 citations

    1

    h-index

1–5 of 360

Institutions

186

  1. Harvard University

    Cambridge, United States

    5 h-index

    23 publications

    2.9K citations

  2. Dana-Farber Cancer Institute

    Boston, United States

    3 h-index

    12 publications

    555 citations

  3. Indiana University – Purdue University Indianapolis

    Indianapolis, United States

    2 h-index

    2 publications

    62 citations

  4. Hôpital Saint-Louis

    Paris, France

    2 h-index

    2 publications

    622 citations

  5. Brigham and Women's Hospital

    Boston, United States

    2 h-index

    2 publications

    88 citations

  6. The University of Texas MD Anderson Cancer Center

    Houston, United States

    2 h-index

    22 publications

    789 citations

  7. Université Claude Bernard Lyon 1

    Villeurbanne, France

    2 h-index

    3 publications

    624 citations

  8. Assistance Publique – Hôpitaux de Paris

    Paris, France

    2 h-index

    3 publications

    1.2K citations

1–8 of 186

Venues

  1. PubMed

    Repository · 7 publications · 1.1K citations

    7

    h-index

  2. British Journal of Dermatology

    3 publications · 101 citations

    3

    h-index

  3. Japanese Journal of Ophthalmology

    2 publications · 24 citations

    2

    h-index

  4. The Lancet

    2 publications · 629 citations

    2

    h-index

  5. Blood

    2 publications · 52 citations

    2

    h-index

1–5