Concepedia

Additivity Modeling

Additivity Modeling is a computational or statistical framework within combination therapy repurposing that quantifies the expected therapeutic effect of a drug pair based on the assumption that their combined effect is the sum of their individual effects, thereby enabling the identification of synergistic or antagonistic interactions by comparison to the additive baseline.

475

Publications

27K

Citations

1.3K

Authors

543

Institutions

Publications per year

2017–2026

67

Parents

Publications

475

Searching for Drug Synergy in Complex Dose–Response Landscapes Using an Interaction Potency Model

Bhagwan Yadav, Krister Wennerberg, Tero Aittokallio et al. · Computational and Structural Biotechnology Journal · 2015 · 878 citations · Full text

, , +14

Drug Synergism: Its Detection and Applications

Ronald J. Tallarida · Journal of Pharmacology and Experimental Therapeutics · 2001 · 686 citations

, , +12

Polar and Nonpolar Interactions in Adhesion

Souheng Wu · The Journal of Adhesion · 1973 · 553 citations

, , +17

Estimation of the Thermodynamic Properties of C-H-N-O-S-Halogen Compounds at 298.15 K

Eugene S. Domalski, Elizabeth D. Hearing · Journal of Physical and Chemical Reference Data · 1993 · 509 citations

, , +15

Application of the Surface Complexation Concept to Complex Mineral Assemblages

James Davis, Jennifer A. Coston, Douglas B. Kent et al. · Environmental Science & Technology · 1998 · 426 citations

, , +17

1–5 of 475

Authors

1.3K

  1. CG
    Chris Gennings

    Icahn School of Medicine at Mount Sinai, United States

    9 publications · 409 citations

    9

    h-index

  2. JE
    Jane Ellen Simmons

    Environmental Protection Agency, United States

    6 publications · 211 citations

    6

    h-index

  3. ZB
    Zvonimir B. Maksić

    Ruđer Bošković Institute, Croatia

    5 publications · 148 citations

    5

    h-index

  4. JF
    Joel F. Liebman

    University of Maryland, Baltimore County, United States

    4 publications · 374 citations

    4

    h-index

  5. PA
    Paul A. White

    Health Canada, Canada

    4 publications · 138 citations

    4

    h-index

1–5 of 1.3K

Institutions

543

  1. Environmental Protection Agency

    Washington, United States

    12 h-index

    27 publications

    775 citations

  2. Centre National de la Recherche Scientifique

    Paris, France

    10 h-index

    23 publications

    910 citations

  3. Research Triangle Park Foundation

    Durham, United States

    9 h-index

    18 publications

    563 citations

  4. University of Illinois Urbana-Champaign

    Urbana, United States

    9 h-index

    15 publications

    610 citations

  5. University of Oxford

    Oxford, United Kingdom

    7 h-index

    17 publications

    965 citations

  6. University of Toronto

    Toronto, Canada

    7 h-index

    11 publications

    779 citations

  7. ETH Zurich

    Zurich, Switzerland

    7 h-index

    14 publications

    548 citations

  8. Ghent University

    Ghent, Belgium

    6 h-index

    19 publications

    486 citations

1–8 of 543

Venues

  1. The Journal of Chemical Physics

    26 publications · 1.5K citations

    23

    h-index

  2. The Journal of Physical Chemistry A

    17 publications · 463 citations

    14

    h-index

  3. Environmental Science & Technology

    11 publications · 1K citations

    11

    h-index

  4. Canadian Journal of Chemistry

    11 publications · 414 citations

    11

    h-index

  5. Journal of Chemical & Engineering Data

    9 publications · 511 citations

    9

    h-index

1–5