Concepedia

Combination Dose Optimization

Combination Dose Optimization is a computational or experimental methodology that identifies the optimal dosage levels of multiple repurposed drugs used in conjunction to maximize therapeutic efficacy while minimizing toxicity and adverse interactions.

80

Publications

3.2K

Citations

524

Authors

278

Institutions

Publications per year

2017–2026

31

Parents

Publications

80

Adapalene-benzoyl peroxide, a fixed-dose combination for the treatment of acne vulgaris: Results of a multicenter, randomized double-blind, controlled study

Diane Thiboutot, Jonathan Weiss, A Bucko et al. · Journal of the American Academy of Dermatology · 2007 · 183 citations

, , +5

Fixed-dose combination of pertuzumab and trastuzumab for subcutaneous injection plus chemotherapy in HER2-positive early breast cancer (FeDeriCa): a randomised, open-label, multicentre, non-inferiority, phase 3 study

Antoinette R. Tan, Seock‐Ah Im, André Mattar et al. · The Lancet Oncology · 2020 · 165 citations

, , +16

On optimal delivery of combination therapy for tumors

Alberto d’Onofrio, Urszula Ledzewicz, Helmut Maurer et al. · Mathematical Biosciences · 2009 · 161 citations

, , +14

Optimizing drug combinations against multiple myeloma using a quadratic phenotypic optimization platform (QPOP)

Masturah Bte Mohd Abdul Rashid, Tan Boon Toh, Lissa Hooi et al. · Science Translational Medicine · 2018 · 124 citations

, , +17

An oral fixed-dose combination of decitabine and cedazuridine in myelodysplastic syndromes: a multicentre, open-label, dose-escalation, phase 1 study

Michael R. Savona, Olatoyosi Odenike, Philip C. Amrein et al. · The Lancet Haematology · 2019 · 120 citations

, , +11

1–5 of 80

Authors

524

  1. XD
    Xianting Ding

    Shanghai Jiao Tong University, China

    5 publications · 211 citations

    5

    h-index

  2. CH
    Chih‐Ming Ho

    University of California, Los Angeles, United States

    4 publications · 271 citations

    4

    h-index

  3. PN
    Patrycja Nowak‐Sliwinska

    École Polytechnique Fédérale de Lausanne, Switzerland

    4 publications · 211 citations

    4

    h-index

  4. HX
    Hongquan Xu

    University of California, Los Angeles, United States

    3 publications · 75 citations

    3

    h-index

  5. AW
    Andrea Weiss

    Amsterdam UMC Location Vrije Universiteit Amsterdam, Netherlands

    3 publications · 156 citations

    3

    h-index

1–5 of 524

Institutions

278

  1. The University of Texas MD Anderson Cancer Center

    Houston, United States

    8 h-index

    17 publications

    1.2K citations

  2. University of California, Los Angeles

    Los Angeles, United States

    8 h-index

    13 publications

    657 citations

  3. Shanghai Jiao Tong University

    Shanghai, China

    6 h-index

    14 publications

    413 citations

  4. Bristol-Myers Squibb (United States)

    New York, United States

    5 h-index

    9 publications

    334 citations

  5. National Cancer Institute

    Bethesda, United States

    3 h-index

    6 publications

    130 citations

  6. Hackensack University Medical Center

    Hackensack, United States

    3 h-index

    3 publications

    154 citations

  7. University of Chicago

    Chicago, United States

    3 h-index

    3 publications

    151 citations

  8. Massachusetts General Hospital

    Boston, United States

    3 h-index

    3 publications

    151 citations

1–8 of 278

Venues

  1. PubMed

    Repository · 7 publications · 159 citations

    7

    h-index

  2. Journal of Clinical Oncology

    4 publications · 91 citations

    4

    h-index

  3. Statistics in Medicine

    2 publications · 130 citations

    3

    h-index

  4. Biometrics

    2 publications · 211 citations

    2

    h-index

  5. Molecules

    2 publications · 72 citations

    2

    h-index

1–5