Concepedia

Combination Efficacy Evaluation

Combination Efficacy Evaluation is a methodological framework within drug repurposing research that systematically assesses the therapeutic synergy, additive effects, or antagonism of paired or higher-order drug combinations through in vitro, in vivo, or in silico models to determine their collective efficacy relative to individual agents.

43

Publications

1.6K

Citations

291

Authors

105

Institutions

Publications per year

2017–2026

12

Parents

Publications

43

Development of Novel Combination Therapies

Janet Woodcock, Joseph P. Griffin, Rachel E. Behrman · New England Journal of Medicine · 2011 · 247 citations

, , +8

Quantifying Drug Combination Synergy along Potency and Efficacy Axes

Christian T. Meyer, David J. Wooten, B. Bishal Paudel et al. · Cell Systems · 2019 · 231 citations

, , +13

BRAID: A Unifying Paradigm for the Analysis of Combined Drug Action

Nathaniel Twarog, Elizabeth Stewart, Courtney Vowell Hammill et al. · Scientific Reports · 2016 · 86 citations · Full text

, , +15

Computationally predicting clinical drug combination efficacy with cancer cell line screens and independent drug action

Alexander Ling, R. Stephanie Huang · Nature Communications · 2020 · 79 citations · Full text

, , +15

Adaptive designs for selecting drug combinations based on efficacy–toxicity response

Vladimir Dragalin, Valerii V. Fedorov, Yuehui Wu · Journal of Statistical Planning and Inference · 2007 · 72 citations

, , +9

1–5 of 43

Authors

291

  1. XJ
    Xiaofan Jiang

    China Medical University, China

    1 publications · 17 citations

    1

    h-index

  2. RQ
    R. Qiu

    Central South University, China

    1 publications · 11 citations

    1

    h-index

  3. JY
    Jason Yongsheng Chan

    National Cancer Centre Singapore, Singapore

    1 publications · 38 citations

    1

    h-index

  4. SJ
    Sheeba Jacob

    Virginia Commonwealth University, United States

    1 publications · 19 citations

    1

    h-index

  5. WJ
    Wee Joo Chng

    National University Cancer Institute, Singapore, Singapore

    1 publications · 38 citations

    1

    h-index

1–5 of 291

Institutions

105

  1. University of Pittsburgh

    Pittsburgh, United States

    2 h-index

    4 publications

    98 citations

  2. University of Pennsylvania

    Philadelphia, United States

    2 h-index

    6 publications

    124 citations

  3. United States Food and Drug Administration

    Silver Spring, United States

    2 h-index

    2 publications

    35 citations

  4. University of Michigan

    Ann Arbor, United States

    2 h-index

    8 publications

    209 citations

  5. Center for Drug Evaluation and Research

    Silver Spring, United States

    2 h-index

    4 publications

    759 citations

  6. Baylor College of Medicine

    Houston, United States

    2 h-index

    3 publications

    57 citations

  7. Children's Hospital of Philadelphia

    Philadelphia, United States

    2 h-index

    6 publications

    124 citations

  8. Pharmacyclics (United States)

    Sunnyvale, United States

    1 h-index

    1 publications

    19 citations

1–8 of 105

Venues

  1. Statistics in Medicine

    5 publications · 116 citations

    5

    h-index

  2. PubMed

    Repository · 5 publications · 88 citations

    5

    h-index

  3. Cell Systems

    1 publications · 231 citations

    1

    h-index

  4. Diabetes Obesity and Metabolism

    1 publications · 11 citations

    1

    h-index

  5. PLoS ONE

    1 publications · 17 citations

    1

    h-index

1–5