Concepedia

Combination Library Design

Combination Library Design is a methodological framework in drug discovery that systematically integrates diverse pharmacological agents into structured combinatorial arrays to enable high-throughput screening for synergistic therapeutic effects.

21

Publications

1.2K

Citations

124

Authors

38

Institutions

Publications per year

2017–2026

4

Parents

Publications

21

High-throughput combinatorial screening identifies drugs that cooperate with ibrutinib to kill activated B-cell–like diffuse large B-cell lymphoma cells

Lesley A. Mathews Griner, Rajarshi Guha, Paul Shinn et al. · Proceedings of the National Academy of Sciences · 2014 · 397 citations · Full text

, , +14

Combinatorial chemistry and molecular diversity in drug discovery

Michael Williams · Drug Development Research · 1998 · 137 citations

, , +16

Efficient discovery of anti-inflammatory small-molecule combinations using evolutionary computing

Ben G. Small, Barry W. McColl, Richard Allmendinger et al. · Nature Chemical Biology · 2011 · 68 citations · Full text

, , +16

Discovery of colon tumor cell growth inhibitory agents through a combinatorial approach

Dalal A. Abouel‐Ella, Jochen Lehmann, Heather N. Tinsley et al. · European Journal of Medicinal Chemistry · 2009 · 61 citations · Full text

, , +12

Identification of Two Novel, Potent, Low-Liability Antinociceptive Compounds from the Direct In Vivo Screening of a Large Mixture-Based Combinatorial Library

Kate J. Reilley, Marc A. Giulianotti, Colette T. Dooley et al. · The AAPS Journal · 2010 · 59 citations · Full text

, , +16

1–5 of 21

Authors

124

  1. SM
    Sam Michael

    National Center for Advancing Translational Sciences, United States

    2 publications · 417 citations

    2

    h-index

  2. MF
    Marc Ferrer

    National Center for Advancing Translational Sciences, United States

    2 publications · 417 citations

    2

    h-index

  3. PS
    Paul Shinn

    National Institutes of Health, United States

    2 publications · 417 citations

    2

    h-index

  4. RA
    Richard A. Houghten

    Torrey Pines Institute For Molecular Studies, United States

    2 publications · 96 citations

    2

    h-index

  5. TM
    Tim Mierzwa

    National Institutes of Health, United States

    2 publications · 417 citations

    2

    h-index

1–5 of 124

Institutions

38

  1. Torrey Pines Institute For Molecular Studies

    San Diego, United States

    3 h-index

    11 publications

    497 citations

  2. National Center for Advancing Translational Sciences

    Rockville, United States

    2 h-index

    37 publications

    10.9K citations

  3. National Cancer Institute

    Bethesda, United States

    2 h-index

    3 publications

    429 citations

  4. General Atomics (United States)

    San Diego, United States

    2 h-index

    4 publications

    127 citations

  5. DSO National Laboratories

    Singapore, Singapore

    1 h-index

    4 publications

    64 citations

  6. University of Edinburgh

    Edinburgh, United Kingdom

    1 h-index

    1 publications

    68 citations

  7. Courant Institute of Mathematical Sciences

    New York, United States

    1 h-index

    1 publications

    58 citations

  8. Roslin Institute

    Dalkeith, United Kingdom

    1 h-index

    1 publications

    68 citations

1–8 of 38

Venues

  1. Molecular Diversity

    2 publications · 37 citations

    2

    h-index

  2. Drug Discovery Today

    2 publications · 84 citations

    2

    h-index

  3. Archives of Pharmacal Research

    1 publications · 23 citations

    1

    h-index

  4. Drug Development Research

    1 publications · 137 citations

    1

    h-index

  5. Nature Chemical Biology

    1 publications · 68 citations

    1

    h-index

1–5