Concepedia

Cis-regulatory Evolution

Cis-Regulatory Evolution is a molecular evolutionary process in which changes in the non-coding regulatory sequences of DNA—such as enhancers, promoters, and silencers—alter the spatial, temporal, or quantitative patterns of gene expression, thereby contributing to phenotypic diversity and adaptation without modifying the protein-coding regions of genes.

375

Publications

35.2K

Citations

2K

Authors

731

Institutions

Publications per year

2017–2026

128

Parents

Publications

375

Effective gene expression prediction from sequence by integrating long-range interactions

Žiga Avsec, Vikram Agarwal, Daniel Visentin et al. · Nature Methods · 2021 · 1.3K citations · Full text

, , +15

Regulatory evolution of innate immunity through co-option of endogenous retroviruses

Edward B. Chuong, Nels C. Elde, Cédric Feschotte · Science · 2016 · 1.1K citations · Full text

, , +17

Evolutionary changes in cis and trans gene regulation

Patricia J. Wittkopp, Belinda K. Haerum, Andrew G. Clark · Nature · 2004 · 958 citations

, , +14

Evolution of metal hyperaccumulation required cis-regulatory changes and triplication of HMA4

Marc Hanikenne, Ina N. Talke, Michael J. Haydon et al. · Nature · 2008 · 801 citations

, , +11

The pineapple genome and the evolution of CAM photosynthesis

Ray Ming, Robert VanBuren, Ching Man Wai et al. · Nature Genetics · 2015 · 734 citations · Full text

, , +15

1–5 of 375

Authors

2K

  1. HB
    Hunter B. Fraser

    Stanford University, United States

    14 publications · 1K citations

    14

    h-index

  2. PJ
    Patricia J. Wittkopp

    University of Michigan, United States

    11 publications · 2.9K citations

    11

    h-index

  3. SS
    Saurabh Sinha

    University of Illinois Urbana-Champaign, United States

    9 publications · 607 citations

    9

    h-index

  4. GA
    Gregory A. Wray

    Duke University, United States

    8 publications · 939 citations

    8

    h-index

  5. DL
    David L. Stern

    Howard Hughes Medical Institute, United States

    7 publications · 1.1K citations

    7

    h-index

1–5 of 2K

Institutions

731

  1. University of Cambridge

    Cambridge, United Kingdom

    24 h-index

    61 publications

    9.6K citations

  2. Howard Hughes Medical Institute

    Chevy Chase, United States

    23 h-index

    67 publications

    14.9K citations

  3. Stanford University

    Stanford, United States

    22 h-index

    82 publications

    8.8K citations

  4. Centre National de la Recherche Scientifique

    Paris, France

    18 h-index

    74 publications

    8.9K citations

  5. University of California, Berkeley

    Berkeley, United States

    18 h-index

    42 publications

    7.2K citations

  6. University of Chicago

    Chicago, United States

    16 h-index

    47 publications

    3.9K citations

  7. University of Michigan

    Ann Arbor, United States

    15 h-index

    33 publications

    4K citations

  8. Harvard University

    Cambridge, United States

    14 h-index

    39 publications

    4.5K citations

1–8 of 731

Venues

  1. Proceedings of the National Academy of Sciences

    PNAS · 32 publications · 3.5K citations

    30

    h-index

  2. Molecular Biology and Evolution

    MBE · 37 publications · 2K citations

    26

    h-index

  3. Genome Research

    GR · 23 publications · 3.4K citations

    23

    h-index

  4. PLoS Genetics

    24 publications · 1.4K citations

    23

    h-index

  5. Genome Biology and Evolution

    GBE · 14 publications · 425 citations

    14

    h-index

1–5