Concepedia

Chromosomal Instability

Chromosomal Instability is a pathological condition characterized by an increased rate of structural or numerical alterations in chromosomes, resulting from defects in DNA repair, cell cycle checkpoints, or mitotic fidelity, which distinguishes it from normal chromosomal maintenance mechanisms.

1.8K

Publications

149.4K

Citations

8.7K

Authors

1.8K

Institutions

Publications per year

2017–2026

241

Variants

Cin

Parents

Children

Publications

1.8K

Telomere shortening associated with chromosome instability is arrested in immortal cells which express telomerase activity.

Christopher M. Counter, Ariel A. Avilion, Catherine LeFeuvre et al. · The EMBO Journal · 1992 · 2.1K citations · Full text

, , +14

Variation of the CGG repeat at the fragile X site results in genetic instability: Resolution of the Sherman paradox

Ying‐Hui Fu, Derek P.A. Kuhl, Antonio Pizzuti et al. · Cell · 1991 · 2.1K citations

, , +8

Genetic instability in colorectal cancers

Christoph Lengauer, Kenneth W. Kinzler, Bert Vogelstein · Nature · 1997 · 2K citations

, , +14

Chromosomal instability drives metastasis through a cytosolic DNA response

Samuel F. Bakhoum, Bryan Ngo, Ashley M. Laughney et al. · Nature · 2018 · 1.6K citations

, , +14

A mechanism linking extra centrosomes to chromosomal instability

Neil J. Ganem, Susana A. Godinho, David Pellman · Nature · 2009 · 1.4K citations · Full text

, , +12

1–5 of 1.8K

Authors

8.7K

  1. TR
    Thomas Ried

    National Cancer Institute, United States

    15 publications · 1.5K citations

    14

    h-index

  2. KJ
    Kirk J. McManus

    University of Manitoba, Canada

    13 publications · 822 citations

    13

    h-index

  3. DA
    Duane A. Compton

    Dartmouth College, United States

    12 publications · 2.3K citations

    12

    h-index

  4. ID
    Ian D. Hickson

    John Radcliffe Hospital, United Kingdom

    12 publications · 2.2K citations

    12

    h-index

  5. CL
    Christoph Lengauer

    Johns Hopkins University, United States

    12 publications · 5K citations

    12

    h-index

1–5 of 8.7K

Institutions

1.8K

  1. Harvard University

    Cambridge, United States

    42 h-index

    200 publications

    41.1K citations

  2. National Institutes of Health

    Bethesda, United States

    32 h-index

    179 publications

    21.6K citations

  3. Memorial Sloan Kettering Cancer Center

    New York, United States

    32 h-index

    123 publications

    39.4K citations

  4. Howard Hughes Medical Institute

    Chevy Chase, United States

    31 h-index

    122 publications

    66K citations

  5. National Cancer Institute

    Bethesda, United States

    29 h-index

    169 publications

    18.6K citations

  6. Johns Hopkins University

    Baltimore, United States

    28 h-index

    132 publications

    25.7K citations

  7. University of California, San Francisco

    San Francisco, United States

    28 h-index

    113 publications

    13.1K citations

  8. Centre National de la Recherche Scientifique

    Paris, France

    28 h-index

    146 publications

    7.8K citations

1–8 of 1.8K

Venues

  1. PubMed

    Repository · 98 publications · 8.4K citations

    50

    h-index

  2. Proceedings of the National Academy of Sciences

    PNAS · 67 publications · 10K citations

    49

    h-index

  3. Molecular and Cellular Biology

    MCB · 44 publications · 4.4K citations

    35

    h-index

  4. Oncogene

    41 publications · 3.2K citations

    34

    h-index

  5. Nature

    36 publications · 16.1K citations

    34

    h-index

1–5