Concepedia

Chaperone-mediated Targeting

Chaperone-Mediated Targeting is a protein localization mechanism in which specific molecular chaperones recognize cytosolic precursor proteins and directly escort them to their destination organelles, distinguishing it from vesicular or signal-independent targeting pathways by its reliance on chaperone-substrate interactions for spatial delivery.

62

Publications

5.1K

Citations

342

Authors

133

Institutions

Publications per year

2017–2026

17

Parents

Publications

62

Molecular Chaperones Hsp90 and Hsp70 Deliver Preproteins to the Mitochondrial Import Receptor Tom70

Jason C. Young, Nicholas J. Hoogenraad, F. Ulrich Hartl · Cell · 2003 · 918 citations · Full text

, , +17

Cell surface expression of the stress response chaperone GRP78 enables tumor targeting by circulating ligands

Marco A. Arap, Johanna Lahdenranta, Paul J. Mintz et al. · Cancer Cell · 2004 · 414 citations · Full text

, , +11

Targeting of the protein chaperone, HSP90, by the transformation suppressing agent, radicicol

Sreenath V. Sharma, Tsutomu Agatsuma, Hirofumi Nakano · Oncogene · 1998 · 278 citations

, , +12

The Mitochondrial Targeting Chaperone 14-3-3ε Regulates a RIG-I Translocon that Mediates Membrane Association and Innate Antiviral Immunity

Helene Minyi Liu, Yueh–Ming Loo, Stacy M. Horner et al. · Cell Host & Microbe · 2012 · 208 citations · Full text

, , +17

Protein Toxin Chaperoned by LRP‐1‐Targeted Virus‐Mimicking Vesicles Induces High‐Efficiency Glioblastoma Therapy In Vivo

Yu Jiang, Weijing Yang, Jian Zhang et al. · Advanced Materials · 2018 · 161 citations

, , +17

1–5 of 62

Authors

342

  1. SS
    Shu‐ou Shan

    California Institute of Technology, United States

    5 publications · 192 citations

    5

    h-index

  2. US
    Un Seng Chio

    University of California, San Francisco, United States

    3 publications · 134 citations

    3

    h-index

  3. TO
    Tsuneo Omura

    Kyushu University, Japan

    2 publications · 255 citations

    2

    h-index

  4. JL
    Jeffrey L. Brodsky

    University of Pittsburgh, United States

    2 publications · 74 citations

    2

    h-index

  5. HC
    Hyun-Ju Cho

    Korea Research Institute of Bioscience and Biotechnology, South Korea

    2 publications · 117 citations

    2

    h-index

1–5 of 342

Institutions

133

  1. California Institute of Technology

    Pasadena, United States

    7 h-index

    24 publications

    1K citations

  2. Centre National de la Recherche Scientifique

    Paris, France

    3 h-index

    14 publications

    1.1K citations

  3. Weizmann Institute of Science

    Rehovot, Israel

    3 h-index

    8 publications

    641 citations

  4. University of California, San Francisco

    San Francisco, United States

    2 h-index

    3 publications

    221 citations

  5. University of California, Los Angeles

    Los Angeles, United States

    2 h-index

    4 publications

    78 citations

  6. Tottori University

    Tottori-shi, Japan

    2 h-index

    6 publications

    195 citations

  7. Howard Hughes Medical Institute

    Chevy Chase, United States

    2 h-index

    5 publications

    283 citations

  8. ETH Zurich

    Zurich, Switzerland

    2 h-index

    2 publications

    149 citations

1–8 of 133

Venues

  1. Journal of Biological Chemistry

    JBC · 7 publications · 340 citations

    7

    h-index

  2. Proceedings of the National Academy of Sciences

    PNAS · 5 publications · 307 citations

    5

    h-index

  3. Cell Reports

    4 publications · 239 citations

    4

    h-index

  4. PLoS ONE

    2 publications · 49 citations

    2

    h-index

  5. Acta Pharmacologica Sinica

    APS · 2 publications · 40 citations

    2

    h-index

1–5