Tsutomu Agatsuma

Targeting of the protein chaperone, HSP90, by the transformation suppressing agent, radicicol

Sreenath V. Sharma, Tsutomu Agatsuma, Hirofumi Nakano · Oncogene · 1998 · 277 citations

Protein Function, Biochemistry, Natural Sciences +5

Interaction of Radicicol with Members of the Heat Shock Protein 90 Family of Molecular Chaperones

Theodor W. Schulte, Shiro Akinaga, T. Murakata et al. · Molecular Endocrinology · 1999 · 154 citations · Full text

Drug Target, Protein Assembly, Hsp90 Alpha +20

KF25706, a novel oxime derivative of radicicol, exhibits in vivo antitumor activity via selective depletion of Hsp90 binding signaling molecules.

Shiro Soga, LM Neckers, T W Schulte et al. · PubMed · 1999 · 137 citations

Hsp90 Binding, Hsp90 Family Proteins, Selective Depletion +16

Halohydrin and Oxime Derivatives of Radicicol: Synthesis and Antitumor Activities

Tsutomu Agatsuma, Harumi Ogawa, Kazuhito Akasaka et al. · Bioorganic & Medicinal Chemistry · 2002 · 111 citations

Oxime Derivatives, Medicinal Chemistry, Derivative (Chemistry) +9

Targeting AMAP1 and cortactin binding bearing an atypical src homology 3/proline interface for prevention of breast cancer invasion and metastasis

Shigeru Hashimoto, Mayumi Hirose, Ari Hashimoto et al. · Proceedings of the National Academy of Sciences · 2006 · 109 citations · Full text

Breast Oncology, Molecular Biology, Cancer Biology +17