Concepedia

Brca1 Deficiency

BRCA1 Deficiency is a genetic dysfunction characterized by the reduced or absent activity of the BRCA1 tumor suppressor protein, impairing homologous recombination DNA repair and increasing susceptibility to genomic instability and cancer.

774

Publications

70K

Citations

5.5K

Authors

1.3K

Institutions

Publications per year

2017–2026

225

Parents

Publications

774

Breast and ovarian cancer incidence in BRCA1-mutation carriers. Breast Cancer Linkage Consortium.

Douglas F. Easton, Deborah Ford, D. Timothy Bishop · PubMed · 1995 · 1.6K citations

, , +16

Aberrant luminal progenitors as the candidate target population for basal tumor development in BRCA1 mutation carriers

Elgene Lim, François Vaillant, Di Wu et al. · Nature Medicine · 2009 · 1.5K citations

, , +16

Brca1 Controls Homology-Directed DNA Repair

Mary Ellen Moynahan, Joanne W Chiu, Beverly H. Koller et al. · Molecular Cell · 1999 · 1.2K citations · Full text

, , +17

Efficacy of Neoadjuvant Cisplatin in Triple-Negative Breast Cancer

Daniel P. Silver, Andrea L. Richardson, Aron C. Eklund et al. · Journal of Clinical Oncology · 2010 · 984 citations · Full text

, , +16

High sensitivity of BRCA1-deficient mammary tumors to the PARP inhibitor AZD2281 alone and in combination with platinum drugs

Sven Rottenberg, Janneke E. Jaspers, Ariena Kersbergen et al. · Proceedings of the National Academy of Sciences · 2008 · 949 citations · Full text

, , +16

1–5 of 774

Authors

5.5K

  1. CD
    Chu‐Xia Deng

    National Institutes of Health, United States

    31 publications · 3.7K citations

    24

    h-index

  2. XX
    Xiaoling Xu

    National Institutes of Health, United States

    25 publications · 3.3K citations

    21

    h-index

  3. JJ
    Jos Jonkers

    The Netherlands Cancer Institute, Netherlands

    22 publications · 3.8K citations

    20

    h-index

  4. SA
    Steven A. Narod

    University of Toronto, Canada

    19 publications · 1.9K citations

    17

    h-index

  5. DM
    David M. Livingston

    Dana-Farber Cancer Institute, United States

    13 publications · 2.6K citations

    12

    h-index

1–5 of 5.5K

Institutions

1.3K

  1. The Netherlands Cancer Institute

    Amsterdam, The Netherlands

    32 h-index

    294 publications

    36.1K citations

  2. National Institutes of Health

    Bethesda, United States

    32 h-index

    148 publications

    25.8K citations

  3. Harvard University

    Cambridge, United States

    30 h-index

    193 publications

    32.8K citations

  4. Dana-Farber Cancer Institute

    Boston, United States

    27 h-index

    201 publications

    64K citations

  5. National Cancer Institute

    Bethesda, United States

    27 h-index

    158 publications

    23.3K citations

  6. National Institute of Diabetes and Digestive and Kidney Diseases

    Bethesda, United States

    26 h-index

    93 publications

    15.3K citations

  7. University of Toronto

    Toronto, Canada

    24 h-index

    100 publications

    14.9K citations

  8. Cancer Genetics (United States)

    Rutherford, United States

    22 h-index

    70 publications

    5.8K citations

1–8 of 1.3K

Venues

  1. Oncogene

    43 publications · 3.7K citations

    33

    h-index

  2. Cancer Research

    30 publications · 2.1K citations

    25

    h-index

  3. Proceedings of the National Academy of Sciences

    PNAS · 25 publications · 4.7K citations

    23

    h-index

  4. Nature Communications

    24 publications · 2K citations

    22

    h-index

  5. Breast Cancer Research and Treatment

    28 publications · 1.5K citations

    22

    h-index

1–5