Concepedia

Braf Dependence

BRAF Dependence is a molecular oncology construct that denotes the phenotypic reliance of certain cancer cells on the continuous activity of the BRAF oncogene for survival and proliferation, distinguishing it from other oncogene-driven dependencies by its specific signaling through the MAPK pathway.

35

Publications

4.8K

Citations

370

Authors

143

Institutions

Publications per year

2017–2026

14

Parents

Publications

35

Kinase-Dead BRAF and Oncogenic RAS Cooperate to Drive Tumor Progression through CRAF

Sonja J. Heidorn, Carla Milagre, Steven R. Whittaker et al. · Cell · 2010 · 1.5K citations · Full text

, , +17

Elevated CRAF as a Potential Mechanism of Acquired Resistance to BRAF Inhibition in Melanoma

Clara Montagut, Sreenath V. Sharma, Toshi Shioda et al. · Cancer Research · 2008 · 504 citations · Full text

, , +17

RAS nucleotide cycling underlies the SHP2 phosphatase dependence of mutant BRAF-, NF1- and RAS-driven cancers

Robert J. Nichols, Franziska Haderk, Carlos Stahlhut et al. · Nature Cell Biology · 2018 · 418 citations

, , +16

Small-molecule MAPK inhibitors restore radioiodine incorporation in mouse thyroid cancers with conditional BRAF activation

Debyani Chakravarty, Elmer Santos, Mabel Ryder et al. · Journal of Clinical Investigation · 2011 · 387 citations

, , +17

The RET/PTC-RAS-BRAF linear signaling cascade mediates the motile and mitogenic phenotype of thyroid cancer cells

Rosa Marina Melillo, Maria Domenica Castellone, Valentina Guarino et al. · Journal of Clinical Investigation · 2005 · 239 citations

, , +17

1–5 of 35

Authors

370

  1. CP
    Catrin Pritchard

    University of Leicester, United Kingdom

    3 publications · 1.8K citations

    3

    h-index

  2. RM
    Richard Marais

    Institute of Cancer Research, United Kingdom

    3 publications · 1.7K citations

    3

    h-index

  3. NR
    Neal Rosen

    Memorial Sloan Kettering Cancer Center, United States

    3 publications · 675 citations

    3

    h-index

  4. BS
    Barry S. Taylor

    Memorial Sloan Kettering Cancer Center, United States

    3 publications · 286 citations

    3

    h-index

  5. TG
    Trever G. Bivona

    University of California, San Francisco, United States

    3 publications · 593 citations

    3

    h-index

1–5 of 370

Institutions

143

  1. Memorial Sloan Kettering Cancer Center

    New York, United States

    6 h-index

    53 publications

    8.5K citations

  2. University of California, San Francisco

    San Francisco, United States

    3 h-index

    20 publications

    4.3K citations

  3. University of Leicester

    Leicester, United Kingdom

    3 h-index

    5 publications

    3.3K citations

  4. University of Chicago

    Chicago, United States

    2 h-index

    4 publications

    1.2K citations

  5. Tri-Institutional PhD Program in Chemical Biology

    New York, United States

    2 h-index

    5 publications

    518 citations

  6. Institute of Cancer Research

    London, United Kingdom

    2 h-index

    10 publications

    13.4K citations

  7. Massachusetts General Hospital

    Boston, United States

    2 h-index

    14 publications

    6.1K citations

  8. Harvard University

    Cambridge, United States

    2 h-index

    13 publications

    6.1K citations

1–8 of 143

Venues

  1. Proceedings of the National Academy of Sciences

    PNAS · 4 publications · 398 citations

    4

    h-index

  2. Nature Communications

    4 publications · 250 citations

    4

    h-index

  3. Journal of Clinical Investigation

    JCI · 3 publications · 727 citations

    3

    h-index

  4. Cancer Research

    2 publications · 568 citations

    2

    h-index

  5. Oncogene

    2 publications · 97 citations

    2

    h-index

1–5