Concepedia

Binding Specificity Optimization

Binding Specificity Optimization is a computational or experimental methodology within antibody engineering that systematically refines the molecular interactions between an antibody and its target antigen to maximize selective binding while minimizing cross-reactivity with non-target epitopes.

31

Publications

1.7K

Citations

229

Authors

67

Institutions

Publications per year

2017–2026

14

Parents

Publications

31

Optimization of therapeutic antibodies by predicting antigen specificity from antibody sequence via deep learning

Derek M. Mason, Simon Friedensohn, Cédric R. Weber et al. · Nature Biomedical Engineering · 2021 · 323 citations · Full text

, , +17

Co-optimization of therapeutic antibody affinity and specificity using machine learning models that generalize to novel mutational space

Emily K. Makowski, Patrick C. Kinnunen, Jie Huang et al. · Nature Communications · 2022 · 157 citations · Full text

, , +17

Antibody complementarity determining region design using high-capacity machine learning

Ge Liu, Haoyang Zeng, Jonas Mueller et al. · Bioinformatics · 2019 · 148 citations · Full text

, , +14

Multivalent Ligand Binding to Cell Membrane Antigens: Defining the Interplay of Affinity, Valency, and Expression Density

Clifford M. Csizmar, Jacob Petersburg, Thomas J. Perry et al. · Journal of the American Chemical Society · 2018 · 103 citations · Full text

, , +17

Antibodies with infinite affinity

Albert J. Chmura, Molly S. Orton, Claude F. Meares · Proceedings of the National Academy of Sciences · 2001 · 102 citations · Full text

, , +17

1–5 of 31

Authors

229

  1. CI
    Chiho Im

    Sanofi (France), France

    2 publications · 46 citations

    2

    h-index

  2. GL
    Ge Liu

    Chinese Academy of Medical Sciences & Peking Union Medical College, China

    2 publications · 172 citations

    2

    h-index

  3. CV
    Chingwei V. Lee

    Genentech

    2 publications · 66 citations

    2

    h-index

  4. JS
    Jonas Schilz

    Allen Institute, United States

    2 publications · 172 citations

    2

    h-index

  5. YQ
    Yu Qiu

    Sanofi (France), France

    2 publications · 46 citations

    2

    h-index

1–5 of 229

Institutions

67

  1. Massachusetts Institute of Technology

    Cambridge, United States

    5 h-index

    25 publications

    1.5K citations

  2. VTT Technical Research Centre of Finland

    Espoo, Finland

    2 h-index

    4 publications

    141 citations

  3. Broad Institute

    Cambridge, United States

    2 h-index

    2 publications

    51 citations

  4. Novartis Institutes for BioMedical Research

    Basel, Switzerland

    2 h-index

    6 publications

    516 citations

  5. Novartis (Switzerland)

    Basel, Switzerland

    2 h-index

    6 publications

    516 citations

  6. Koch Institute for Integrative Cancer Research At MIT

    Cambridge, United States

    2 h-index

    2 publications

    172 citations

  7. Allen Institute

    Seattle, United States

    2 h-index

    2 publications

    172 citations

  8. Sanofi (France)

    Paris, France

    2 h-index

    9 publications

    225 citations

1–8 of 67

Venues

  1. bioRxiv (Cold Spring Harbor Laboratory)

    Repository · 2 publications · 41 citations

    2

    h-index

  2. Protein Engineering Design and Selection

    PEDS · 2 publications · 127 citations

    2

    h-index

  3. Journal of the American Chemical Society

    JACS · 2 publications · 129 citations

    2

    h-index

  4. Journal of Immunological Methods

    2 publications · 26 citations

    2

    h-index

  5. PLoS ONE

    2 publications · 71 citations

    2

    h-index

1–5