Concepedia

Binding Affinity Evolution

Binding Affinity Evolution is a computational framework that models the quantitative changes in protein-protein interaction strength over evolutionary time, distinguished by its integration of sequence divergence, structural constraints, and biophysical principles to predict affinity variations across homologous protein interfaces.

80

Publications

4K

Citations

420

Authors

173

Institutions

Publications per year

2017–2026

38

Parents

Publications

80

A topology-based network tree for the prediction of protein–protein binding affinity changes following mutation

Menglun Wang, Zixuan Cang, Guo‐Wei Wei · Nature Machine Intelligence · 2020 · 220 citations · Full text

, , +13

Enhanced binding of the N501Y‐mutated SARS‐CoV‐2 spike protein to the human ACE2 receptor: insights from molecular dynamics simulations

Binquan Luan, Haoran Wang, Tien Huynh · FEBS Letters · 2021 · 203 citations · Full text

, , +16

Repeated losses of PRDM9-directed recombination despite the conservation of PRDM9 across vertebrates

Zachary Baker, Molly Schumer, Yuki Haba et al. · eLife · 2017 · 164 citations · Full text

, , +17

Water Networks Can Determine the Affinity of Ligand Binding to Proteins

John F. Darby, Adam P. Hopkins, Seishi Shimizu et al. · Journal of the American Chemical Society · 2019 · 155 citations

, , +17

BindProfX: Assessing Mutation-Induced Binding Affinity Change by Protein Interface Profiles with Pseudo-Counts

Peng Xiong, Chengxin Zhang, Wei Zheng et al. · Journal of Molecular Biology · 2016 · 153 citations

, , +14

1–5 of 80

Authors

420

  1. CY
    Chaoyong Yang

    Xiamen University, China

    2 publications · 166 citations

    3

    h-index

  2. KH
    Kabir H. Biswas

    Hamad bin Khalifa University, Qatar

    2 publications · 36 citations

    2

    h-index

  3. OD
    Orly Dym

    Weizmann Institute of Science, Israel

    2 publications · 206 citations

    2

    h-index

  4. NP
    Nicholas P.J. Brindle

    University of Leicester, United Kingdom

    2 publications · 68 citations

    2

    h-index

  5. AL
    Ashley L. Taylor

    University of Utah, United States

    2 publications · 68 citations

    2

    h-index

1–5 of 420

Institutions

173

  1. Hebrew University of Jerusalem

    Jerusalem, Israel

    4 h-index

    7 publications

    256 citations

  2. Centre National de la Recherche Scientifique

    Paris, France

    4 h-index

    11 publications

    642 citations

  3. University of Michigan

    Ann Arbor, United States

    3 h-index

    7 publications

    922 citations

  4. Chinese Academy of Sciences

    Beijing, China

    3 h-index

    5 publications

    619 citations

  5. University of York

    York, United Kingdom

    3 h-index

    9 publications

    1.1K citations

  6. University of Leicester

    Leicester, United Kingdom

    3 h-index

    11 publications

    526 citations

  7. Weizmann Institute of Science

    Rehovot, Israel

    3 h-index

    13 publications

    1.3K citations

  8. Xiamen University

    Xiamen, China

    3 h-index

    14 publications

    1.2K citations

1–8 of 173

Venues

  1. Journal of Molecular Biology

    JMB · 4 publications · 336 citations

    4

    h-index

  2. PLoS ONE

    4 publications · 107 citations

    4

    h-index

  3. PLoS Pathogens

    3 publications · 151 citations

    3

    h-index

  4. bioRxiv (Cold Spring Harbor Laboratory)

    Repository · 3 publications · 145 citations

    3

    h-index

  5. Proceedings of the National Academy of Sciences

    PNAS · 3 publications · 180 citations

    3

    h-index

1–5