Concepedia

Binder Specificity Optimization

Binder Specificity Optimization is a methodological framework in phage display technology that systematically enhances the selective binding affinity of molecular binders to target antigens while minimizing cross-reactivity with non-target molecules.

18

Publications

987

Citations

98

Authors

38

Institutions

Publications per year

2017–2026

2

Parents

Publications

18

Efficient Selection of DARPins with Sub-nanomolar Affinities using SRP Phage Display

Daniel Steiner, Patrik Forrer, Andreas Plückthun · Journal of Molecular Biology · 2008 · 267 citations

, , +11

Selection of large diversities of antiidiotypic antibody fragments by phage display

Steffen Goletz, Peter Astrup Christensen, Peter Kristensen et al. · Journal of Molecular Biology · 2002 · 138 citations

, , +15

Small binding proteins selected from a combinatorial repertoire of knottins displayed on phage

Geoff Smith, Sunil U. Patel, John D. Windass et al. · Journal of Molecular Biology · 1998 · 114 citations

, , +10

Subtractive single-chain antibody (scFv) phage-display: tailoring phage-display for high specificity against function-specific conformations of cell membrane molecules

Steffen U. Eisenhardt, Meike Schwarz, Nicole Bassler et al. · Nature Protocols · 2007 · 70 citations

, , +15

Selection of single domain binding proteins by covalent DNA display

Julian Bertschinger, Dragan Grabulovski, Dario Neri · Protein Engineering Design and Selection · 2007 · 60 citations

, , +15

1–5 of 18

Authors

98

  1. GW
    Greg Winter

    MRC Laboratory of Molecular Biology, United Kingdom

    2 publications · 252 citations

    2

    h-index

  2. GÅ
    Geir Åge Løset

    University of Oslo, Norway

    1 publications · 21 citations

    1

    h-index

  3. BA
    Bruce A. Malcolm

    University of Alberta, Canada

    1 publications · 10 citations

    1

    h-index

  4. AF
    András Fiser

    Albert Einstein College of Medicine, United States

    1 publications · 19 citations

    1

    h-index

  5. UK
    Uwe Karsten

    Max Delbrück Center, Germany

    1 publications · 138 citations

    1

    h-index

1–5 of 98

Institutions

38

  1. MRC Laboratory of Molecular Biology

    Cambridge, United Kingdom

    3 h-index

    5 publications

    540 citations

  2. KTH Royal Institute of Technology

    Stockholm, Sweden

    2 h-index

    6 publications

    210 citations

  3. Affibody (Sweden)

    Solna, Sweden

    2 h-index

    3 publications

    84 citations

  4. Turku Centre for Biotechnology

    Turku, Finland

    1 h-index

    5 publications

    280 citations

  5. Acentech (United States)

    Cambridge, United States

    1 h-index

    2 publications

    30 citations

  6. University of Turku

    Turku, Finland

    1 h-index

    5 publications

    280 citations

  7. Wroclaw Research Centre EIT+ (Poland)

    Wrocław, Poland

    1 h-index

    1 publications

    33 citations

  8. ETH Zurich

    Zurich, Switzerland

    1 h-index

    1 publications

    60 citations

1–8 of 38

Venues

  1. Protein Engineering Design and Selection

    PEDS · 3 publications · 105 citations

    3

    h-index

  2. Journal of Molecular Biology

    JMB · 3 publications · 519 citations

    3

    h-index

  3. Biotechnology and Applied Biochemistry

    2 publications · 63 citations

    2

    h-index

  4. PLoS ONE

    2 publications · 57 citations

    2

    h-index

  5. Scientific Reports

    2 publications · 37 citations

    2

    h-index

1–5