Concepedia

Allele-specific Sensitivity

Allele-Specific Sensitivity is a pharmacogenetic phenomenon in forward chemical genetics wherein a cellular or organismal response to a bioactive compound is differentially modulated by the presence of a specific mutant allele relative to its wild-type counterpart, thereby revealing gene function through differential chemical susceptibility.

8

Publications

564

Citations

49

Authors

25

Institutions

Publications per year

2017–2026

2

Parents

Publications

8

Optimization of Ribosome Structure and Function by rRNA Base Modification

Jennifer L. Baxter-Roshek, Alexey Petrov, Jonathan D. Dinman · PLoS ONE · 2007 · 137 citations · Full text

, , +17

Fc gamma receptor IIIb enhances Fc gamma receptor IIa function in an oxidant-dependent and allele-sensitive manner.

J E Salmon, S. Sean Millard, N L Brogle et al. · Journal of Clinical Investigation · 1995 · 119 citations · Full text

, , +15

On-target Resistance to the Mutant-Selective EGFR Inhibitor Osimertinib Can Develop in an Allele-Specific Manner Dependent on the Original EGFR-Activating Mutation

Benjamin P. Brown, Yunkai Zhang, David Westover et al. · Clinical Cancer Research · 2019 · 107 citations · Full text

, , +17

Design and Use of Analog‐Sensitive Protein Kinases

Justin D. Blethrow, Chao Zhang, Kevan M. Shokat et al. · Current Protocols in Molecular Biology · 2004 · 60 citations

, , +10

An aspartate deletion mutation defines a binding site of the multifunctional FhuA outer membrane receptor of Escherichia coli K-12

Helmut Killmann, V Braun · Journal of Bacteriology · 1992 · 58 citations · Full text

, , +17

1–5 of 8

Authors

49

  1. HQ
    Huan Qiao

    Vanderbilt University, United States

    1 publications · 107 citations

    1

    h-index

  2. CL
    Charles L. Sentman

    Dartmouth College, United States

    1 publications · 45 citations

    1

    h-index

  3. TK
    Thomas Kroj

    Centre de Coopération Internationale en Recherche Agronomique pour le Développement, France

    1 publications · 23 citations

    1

    h-index

  4. MB
    Maël Baudin

    Centre National de la Recherche Scientifique, France

    1 publications · 23 citations

    1

    h-index

  5. BZ
    Bo Zhou

    International Rice Research Institute, Philippines

    1 publications · 23 citations

    1

    h-index

1–5 of 49

Institutions

25

  1. The University of Texas at Austin

    Austin, United States

    1 h-index

    1 publications

    15 citations

  2. Karolinska Institutet

    Stockholm, Sweden

    1 h-index

    6 publications

    270 citations

  3. Hospital for Special Surgery

    New York, United States

    1 h-index

    3 publications

    357 citations

  4. Centre Occitanie-Montpellier

    Montpellier, France

    1 h-index

    10 publications

    230 citations

  5. Université de Montpellier

    Montpellier, France

    1 h-index

    10 publications

    230 citations

  6. International Rice Research Institute

    Los Baños, Philippines

    1 h-index

    3 publications

    69 citations

  7. China National Hybrid Rice R&D Central Hunan Hybrid Rice Reserch Center

    Changsha, China

    1 h-index

    2 publications

    46 citations

  8. Ferdowsi University of Mashhad

    Mashhad, Iran

    1 h-index

    1 publications

    23 citations

1–8 of 25

Venues

  1. Genetics

    1 publications · 15 citations

    1

    h-index

  2. PLoS ONE

    1 publications · 137 citations

    1

    h-index

  3. The Journal of Immunology

    JI · 1 publications · 45 citations

    1

    h-index

  4. Journal of Clinical Investigation

    JCI · 1 publications · 119 citations

    1

    h-index

  5. Clinical Cancer Research

    1 publications · 107 citations

    1

    h-index

1–5