Concepedia

Aggregation Propensity

Aggregation Propensity is a biophysical metric that quantifies the inherent tendency of a polypeptide sequence to undergo self-association into insoluble, non-native aggregates as a result of intermolecular interactions driven by hydrophobic, electrostatic, and conformational factors during protein folding or misfolding.

643

Publications

34.2K

Citations

3.1K

Authors

908

Institutions

Publications per year

2017–2026

244

Variants

Protein Aggregation Propensity

Parents

Publications

643

AGGRESCAN: a server for the prediction and evaluation of "hot spots" of aggregation in polypeptides

Oscar Conchillo‐Solé, Natalia Sánchez de Groot, Francesc Avilés et al. · BMC Bioinformatics · 2007 · 1.1K citations · Full text

, , +17

Design of therapeutic proteins with enhanced stability

Naresh Chennamsetty, Vladimir Voynov, Veysel Kayser et al. · Proceedings of the National Academy of Sciences · 2009 · 597 citations · Full text

, , +17

Membrane-bound α-Synuclein Has a High Aggregation Propensity and the Ability to Seed the Aggregation of the Cytosolic Form

He-Jin Lee, Chan Choi, Seung‐Jae Lee · Journal of Biological Chemistry · 2002 · 454 citations · Full text

, , +17

An Aggregation Advisor for Ligand Discovery

John J. Irwin, Da Duan, Hayarpi Torosyan et al. · Journal of Medicinal Chemistry · 2015 · 429 citations · Full text

, , +16

Bimodal protein solubility distribution revealed by an aggregation analysis of the entire ensemble of <i>Escherichia coli</i> proteins

Tatsuya Niwa, Bei‐Wen Ying, Katsuyo Saito et al. · Proceedings of the National Academy of Sciences · 2009 · 340 citations · Full text

, , +15

1–5 of 643

Authors

3.1K

  1. SV
    Salvador Ventura

    Universitat Autònoma de Barcelona, Spain

    22 publications · 1.9K citations

    16

    h-index

  2. CM
    Christopher M. Dobson

    University of Cambridge, United Kingdom

    12 publications · 1.1K citations

    12

    h-index

  3. MV
    Michele Vendruscolo

    University of Cambridge, United Kingdom

    12 publications · 985 citations

    11

    h-index

  4. FC
    Fabrizio Chiti

    University of Florence, Italy

    10 publications · 661 citations

    10

    h-index

  5. FR
    Frédéric Rousseau

    KU Leuven, Belgium

    8 publications · 439 citations

    8

    h-index

1–5 of 3.1K

Institutions

908

  1. University of Cambridge

    Cambridge, United Kingdom

    20 h-index

    77 publications

    7.1K citations

  2. Universitat Autònoma de Barcelona

    Cerdanyola del Vallès, Spain

    17 h-index

    87 publications

    9.9K citations

  3. Centre National de la Recherche Scientifique

    Paris, France

    14 h-index

    91 publications

    3.1K citations

  4. Massachusetts Institute of Technology

    Cambridge, United States

    13 h-index

    48 publications

    4.8K citations

  5. The University of Osaka

    Osaka, Japan

    12 h-index

    42 publications

    4K citations

  6. University of Florence

    Florence, Italy

    12 h-index

    34 publications

    1.7K citations

  7. KU Leuven

    Leuven, Belgium

    10 h-index

    52 publications

    2.9K citations

  8. University of Kansas

    Lawrence, United States

    10 h-index

    37 publications

    1.7K citations

1–8 of 908

Venues

  1. Biochemistry

    37 publications · 2K citations

    27

    h-index

  2. PLoS ONE

    31 publications · 1.5K citations

    23

    h-index

  3. Journal of the American Chemical Society

    JACS · 18 publications · 1.2K citations

    17

    h-index

  4. Proceedings of the National Academy of Sciences

    PNAS · 17 publications · 2.4K citations

    16

    h-index

  5. The Journal of Physical Chemistry B

    23 publications · 807 citations

    16

    h-index

1–5