The aldo-keto reductase AKR1C3 is a novel suppressor of cell differentiation that provides a plausible target for the non-cyclooxygenase-dependent antineoplastic actions of nonsteroidal anti-inflammatory drugs.

Julian C. Desmond, Joanne C. Mountford, Mark T. Drayson, +7

PubMed

Chemoprevention StrategyCell DeathCell DifferentiationTumor BiologyOxidative Stress +18

Supramolecular Iron Cylinder with Unprecedented DNA Binding Is a Potent Cytostatic and Apoptotic Agent without Exhibiting Genotoxicity

A.C.G. Hotze, Nikolas J. Hodges, Rachel E. Hayden, +7

Chemistry & Biology

Bioorganic ChemistryBiochemistryNatural SciencesMedicineMetalloprotein +10

The aldo-keto reductase AKR1C3 contributes to 7,12-dimethylbenz(a)anthracene-3,4-dihydrodiol mediated oxidative DNA damage in myeloid cells: Implications for leukemogenesis

Jane Birtwistle, Rachel E. Hayden, Farhat L. Khanim, +8

Mutation research. Fundamental and molecular mechanisms of mutagenesis

Hematological MalignancyReductive StressAldo-keto Reductase Akr1c3Oxidative Dna DamageBiochemistry +10

Combined Bezafibrate and Medroxyprogesterone Acetate: Potential Novel Therapy for Acute Myeloid Leukaemia

Farhat L. Khanim, Rachel E. Hayden, Jane Birtwistle, +12

PLoS ONE

AKR1C Isoforms Represent a Novel Cellular Target for Jasmonates alongside Their Mitochondrial-Mediated Effects

Nicholas Davies, Rachel E. Hayden, Paul J. Simpson, +4

Cancer Research

Drug Redeployment to Kill Leukemia and Lymphoma Cells by Disrupting SCD1-Mediated Synthesis of Monounsaturated Fatty Acids

Andrew D. Southam, Farhat L. Khanim, Rachel E. Hayden, +6

Cancer Research

Use of a molecular beacon to track the activity of base excision repair protein OGG1 in live cells

Leda Mirbahai, Rachael M. Kershaw, Richard M. Green, +3

DNA repair

Live CellsCell DivisionMedicineMolecular BeaconNatural Sciences +7

Combined bezafibrate and medroxyprogesterone acetate have efficacy without haematological toxicity in elderly and relapsed acute myeloid leukaemia (AML)

J. A. H. Murray, Farhat L. Khanim, Rachel E. Hayden, +5

British Journal of Haematology

Mixed-phenotype Acute LeukemiaImmunologyPharmacotherapyImmunotherapyPlatelet Transfusion +14

Nm23-H1 Indirectly Promotes the Survival of Acute Myeloid Leukemia Blast Cells by Binding to More Mature Components of the Leukemic Clone

Andrew J. Lilly, Farhat L. Khanim, Rachel E. Hayden, +3

Cancer Research

Serum Nm23-h1 ProteinMixed-phenotype Acute LeukemiaImmunologyCancer BiologyTumor Biology +14

Analysis of the role of COP9 Signalosome (CSN) subunits in K562; the first link between CSN and autophagy

Claire Pearce, Rachel E. Hayden, Christopher M. Bunce, +1

BMC Cell Biology