Fang‐Tsao Hong

Stereocontrolled Synthesis of Triazacyclopenta[<i>cd</i>]pentalenes by Intramolecular 1,3-Dipolar Cycloaddition Reactions of Azomethine Imines

Guillaume Bélanger, Fang‐Tsao Hong, Larry E. Overman et al. · The Journal of Organic Chemistry · 2002 · 54 citations

Azomethine Imines, Alpha-ketoester Side Chain, Engineering +14

Selective Class I Phosphoinositide 3-Kinase Inhibitors: Optimization of a Series of Pyridyltriazines Leading to the Identification of a Clinical Candidate, AMG 511

Mark H. Norman, Kristin L. Andrews, Yunxin Bo et al. · Journal of Medicinal Chemistry · 2012 · 50 citations · Full text

Chemoprevention Strategy, Molecular Biology, Clinical Candidate +19

Structure-Based Design of a Novel Series of Potent, Selective Inhibitors of the Class I Phosphatidylinositol 3-Kinases

Adrian L. Smith, Noel D. D’Angelo, Yunxin Bo et al. · Journal of Medicinal Chemistry · 2012 · 49 citations · Full text

Discovery and Structure-Guided Optimization of Diarylmethanesulfonamide Disrupters of Glucokinase–Glucokinase Regulatory Protein (GK–GKRP) Binding: Strategic Use of a N → S (n_N → σ*_S–X) Interaction for Conformational Constraint

Lewis D. Pennington, Michael D. Bartberger, Michael D. Croghan et al. · Journal of Medicinal Chemistry · 2015 · 38 citations · Full text

Molecular Biology, Peptide Science, Analytical Ultracentrifugation +22

Cytochrome P450-Mediated Epoxidation of 2-Aminothiazole-Based AKT Inhibitors: Identification of Novel GSH Adducts and Reduction of Metabolic Activation through Structural Changes Guided by in Silico and in Vitro Screening

Raju Subramanian, Matthew R. Lee, John G. Allen et al. · Chemical Research in Toxicology · 2010 · 30 citations

Medicinal Chemistry, Novel Gsh Adducts, Biochemistry +15