Enantioselective Total Synthesis of Aspidophytine

Feng He, Yunxin Bo, Jason Altom, +1

Journal of the American Chemical Society

Diversity Oriented SynthesisBioorganic ChemistryEngineeringBiochemistryNatural Sciences +12

Highly Enantioselective Phase Transfer Catalyzed Alkylation of a 3-Oxygenated Propionic Ester Equivalent; Applications and Mechanism

E. J. Corey, Yunxin Bo, Jakob Busch‐Petersen

Journal of the American Chemical Society

Chemical EngineeringEngineeringAlkene MetathesisAltmetric Attention ScoreOrganic Chemistry +8

Discovery of Potent, Orally Available Vanilloid Receptor-1 Antagonists. Structure−Activity Relationship of <i>N</i>-Aryl Cinnamides

Elizabeth M. Doherty, Christopher Fotsch, Yunxin Bo, +14

Journal of Medicinal Chemistry

Transient Receptor PotentialMolecular PainPharmacotherapyMedicinal ChemistryVanilloid Receptor-1 +14

Novel Vanilloid Receptor-1 Antagonists:  2. Structure−Activity Relationships of 4-Oxopyrimidines Leading to the Selection of a Clinical Candidate

Elizabeth M. Doherty, Christopher Fotsch, Anthony W. Bannon, +16

Journal of Medicinal Chemistry

Design of Potent, Orally Available Antagonists of the Transient Receptor Potential Vanilloid 1. Structure−Activity Relationships of 2-Piperazin-1-yl-1<i>H</i>-benzimidazoles

Vassil I. Ognyanov, Balan Chenera, Anthony W. Bannon, +15

Journal of Medicinal Chemistry

Drug TargetPain MedicineNeuropathic PainMolecular PainCompound 46Ad +19

Phospshoinositide 3-Kinase (PI3K)/Mammalian Target of Rapamycin (mTOR) Dual Inhibitors: Discovery and Structure–Activity Relationships of a Series of Quinoline and Quinoxaline Derivatives

Nobuko Nishimura, Aaron Siegmund, Longbin Liu, +19

Journal of Medicinal Chemistry

Fused Piperidines as a Novel Class of Potent and Orally Available Transient Receptor Potential Melastatin Type 8 (TRPM8) Antagonists

Nuria Tamayo, Yunxin Bo, Vijay Gore, +13

Journal of Medicinal Chemistry

Selective Class I Phosphoinositide 3-Kinase Inhibitors: Optimization of a Series of Pyridyltriazines Leading to the Identification of a Clinical Candidate, AMG 511

Mark H. Norman, Kristin L. Andrews, Yunxin Bo, +34

Journal of Medicinal Chemistry

Chemoprevention StrategyMolecular BiologyClinical CandidatePharmacotherapyChemical Biology +17

Structure-Based Design of a Novel Series of Potent, Selective Inhibitors of the Class I Phosphatidylinositol 3-Kinases

Adrian L. Smith, Noel D. D’Angelo, Yunxin Bo, +29

Journal of Medicinal Chemistry

New, practical and effective sources of fluoride ion for desilylation to form carbon anions

Jakob Busch‐Petersen, Yunxin Bo, E.J. Corey

Tetrahedron Letters

Chemical EngineeringCarbonizationEngineeringCarbon AnionsFluorous Synthesis +5