Promotion of sleep by targeting the orexin system in rats, dogs and humans

Catherine Brisbare‐Roch, Jasper Dingemanse, Ralf Koberstein, +15

Nature Medicine

Animal PhysiologySleep DisordersSleepSleep MedicineSleep Disorder +13

Pharmacology of Macitentan, an Orally Active Tissue-Targeting Dual Endothelin Receptor Antagonist

Marc Iglarz, Christoph A. Binkert, Keith Morrison, +11

Journal of Pharmacology and Experimental Therapeutics

Pharmacology of the Urotensin-II Receptor Antagonist Palosuran (ACT-058362; 1-[2-(4-Benzyl-4-hydroxy-piperidin-1-yl)-ethyl]-3-(2-methyl-quinolin-4-yl)-urea Sulfate Salt): First Demonstration of a Pathophysiological Role of the Urotensin System

Martine Clozel, Christoph A. Binkert, Magdalena Birker, +16

Journal of Pharmacology and Experimental Therapeutics

Acute changes in urinary excretion of nitrite + nitrate do not necessarily predict renal vascular NO production

Tamás Sütö, György Losonczy, Changbin Qiu, +6

Kidney International

UrologyRenal FunctionUrinary ExcretionSodium HomeostasisMedicine +9

Bosentan, sildenafil, and their combination in the monocrotaline model of pulmonary hypertension in rats.

Martine Clozel, Patrick Hess, Markus Rey, +3

PubMed

HypertensionHeart FailureCardiovascular PharmacologyPulmonary HypertensionPharmacotherapy +18

Cellular basis for blunted volume expansion natriuresis in experimental nephrotic syndrome.

Jean‐Pierre Valentin, Changbin Qiu, William P. Muldowney, +3

Journal of Clinical Investigation

Renal PathologyRenal InflammationGlomerulonephritisRenal FunctionCellular Basis +17

The Urotensin-II Receptor Antagonist Palosuran Improves Pancreatic and Renal Function in Diabetic Rats

Martine Clozel, Patrick Hess, Changbin Qiu, +2

Journal of Pharmacology and Experimental Therapeutics

Evolution of Chronic Nitric Oxide Inhibition Hypertension

Changbin Qiu, Dianne G. Muchant, William H. Beierwaltes, +2

Hypertension

Chronic Endothelin Receptor Blockade Prevents Both Early Hyperfiltration and Late Overt Diabetic Nephropathy in the Rat

Shuangshuang Ding, Changbin Qiu, Patrick Hess, +3

Journal of Cardiovascular Pharmacology

HypertensionAce InhibitionRenal InflammationGlomerulonephritisRenal Function +14

Endothelin modulates the pressor actions of acute systemic nitric oxide blockade.

Changbin Qiu, Kevin Engels, Christine Baylis

Journal of the American Society of Nephrology

InflammationHypertensionBlood PressureMedicineVascular Pharmacology +11