The Achilles’ heel of senescent cells: from transcriptome to senolytic drugs

Yi Zhu, Tamar Tchkonia, Tamar Pirtskhalava, +30

Aging Cell

ApoptosisImmunologyImmune RegulationCell DeathImmunotherapeutics +16

Fisetin is a senotherapeutic that extends health and lifespan

Matthew J. Yousefzadeh, Yi Zhu, Sara J. McGowan, +19

EBioMedicine

Identification of HSP90 inhibitors as a novel class of senolytics

Heike Fuhrmann‐Stroissnigg, Yuan Yuan Ling, Jing Zhao, +17

Nature Communications

Structure-Activity Relationships and X-ray Structures Describing the Selectivity of Aminopyrazole Inhibitors for c-Jun N-terminal Kinase 3 (JNK3) over p38

Ted Kamenecka, Jeff E. Habel, Derek R. Duckett, +7

Journal of Biological Chemistry

X-ray StructuresDrug TargetBiochemistryMedicineNatural Sciences +9

Small Molecule c-jun-N-Terminal Kinase Inhibitors Protect Dopaminergic Neurons in a Model of Parkinson’s Disease

Jeremy W. Chambers, Alok S. Pachori, Shannon Howard, +12

ACS Chemical Neuroscience

Neurochemical BiomarkersPharmacotherapyMolecular PharmacologyMedicinal ChemistryPrimary Dopaminergic Neurons +17

Synthesis, Biological Evaluation, X-ray Structure, and Pharmacokinetics of Aminopyrimidine c-jun-N-terminal Kinase (JNK) Inhibitors

Ted Kamenecka, Rong Jiang, Xinyi Song, +11

Journal of Medicinal Chemistry

Isolated Rat Hepatocytes Bind Lactoferrins by the RHL-1 Subunit of the Asialoglycoprotein Receptor in a Galactose-Independent Manner

David J. Bennatt, Yuan Yuan Ling, Douglas D. McAbee

Biochemistry

3,5-Disubstituted quinolines as novel c-Jun N-terminal kinase inhibitors

Rong Jiang, Derek R. Duckett, Wei‐Ming Chen, +4

Bioorganic & Medicinal Chemistry Letters

Molecular PharmacologyMedicinal Chemistry3,5-Disubstituted QuinolinesMedicineMechanism Of Action +4

Synthesis and SAR of piperazine amides as novel c-jun N-terminal kinase (JNK) inhibitors

Youseung Shin, Wei‐Ming Chen, Jeff E. Habel, +7

Bioorganic & Medicinal Chemistry Letters

Molecular PharmacologyMedicinal ChemistryDrug TargetPiperazine AmidesMedicine +10

Synthesis and SAR of novel quinazolines as potent and brain-penetrant c-jun N-terminal kinase (JNK) Inhibitors

Yuanjun He, Theodore M. Kamenecka, Youseung Shin, +11

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryDrug TargetMedicineDrug DiscoveryNovel Quinazolines +9