Yuan Yuan Ling

The Achilles’ heel of senescent cells: from transcriptome to senolytic drugs

Yi Zhu, Tamar Tchkonia, Tamar Pirtskhalava et al. · Aging Cell · 2015 · 2.3K citations · Full text

Apoptosis, Immunology, Immune Regulation +18

Fisetin is a senotherapeutic that extends health and lifespan

Matthew J. Yousefzadeh, Yi Zhu, Sara J. McGowan et al. · EBioMedicine · 2018 · 913 citations · Full text

Identification of HSP90 inhibitors as a novel class of senolytics

Heike Fuhrmann‐Stroissnigg, Yuan Yuan Ling, Jing Zhao et al. · Nature Communications · 2017 · 651 citations · Full text

Structure-Activity Relationships and X-ray Structures Describing the Selectivity of Aminopyrazole Inhibitors for c-Jun N-terminal Kinase 3 (JNK3) over p38

Ted Kamenecka, Jeff E. Habel, Derek R. Duckett et al. · Journal of Biological Chemistry · 2009 · 70 citations · Full text

X-ray Structures, Drug Target, Biochemistry +11

Small Molecule c-jun-N-Terminal Kinase Inhibitors Protect Dopaminergic Neurons in a Model of Parkinson’s Disease

Jeremy W. Chambers, Alok S. Pachori, Shannon Howard et al. · ACS Chemical Neuroscience · 2011 · 69 citations · Full text

Neurochemical Biomarkers, Pharmacotherapy, Molecular Pharmacology +19