Differential effects of anti-B7-1 and anti-B7-2 monoclonal antibody treatment on the development of diabetes in the nonobese diabetic mouse.

Deborah J. Lenschow, Shu‐Chuan Ho, Husain Sattar, +5

The Journal of Experimental Medicine

ImmunologyPathologyImmunotherapyInsulin SignalingImmune Dysregulation +15

Human T-cell clonal anergy is induced by antigen presentation in the absence of B7 costimulation.

Claude Gimmi, G J Freeman, John G. Gribben, +2

Proceedings of the National Academy of Sciences

Adaptive Immune SystemHla ImmunogeneticsImmunologyImmunodominanceImmunologic Mechanism +16

Structure, expression, and T cell costimulatory activity of the murine homologue of the human B lymphocyte activation antigen B7.

Gordon J. Freeman, G S Gray, Claude Gimmi, +6

The Journal of Experimental Medicine

Lymphocyte DevelopmentAdaptive Immune SystemT-regulatory CellImmunologyMurine B7 +19

CTLA4 mediates antigen-specific apoptosis of human T cells.

John G. Gribben, Gordon J. Freeman, Vassiliki A. Boussiotis, +7

Proceedings of the National Academy of Sciences

AllergyAutoimmune DiseaseT CellsClonal DeletionT-regulatory Cell +13

Characterization of CTLA-4 structure and expression on human T cells.

Tullia Lindsten, K P Lee, Estelle S. Harris, +7

The Journal of Immunology

Differential up-regulation of the B7-1 and B7-2 costimulatory molecules after Ig receptor engagement by antigen.

Deborah J. Lenschow, Anne I. Sperling, Michael P. Cooke, +7

The Journal of Immunology

Ag-pulsed B CellsAdaptive Immune SystemImmune RegulationImmunologyImmunologic Mechanism +19

Immunosuppressive effects of human CTLA4Ig in a non-human primate model of allogeneic pancreatic islet transplantation

Matteo Levisetti, Philip Padrid, Gregory L. Szot, +7

The Journal of Immunology

Expression and functional significance of an additional ligand for CTLA-4.

Deborah J. Lenschow, Gloria H. Su, L Zuckerman, +5

Proceedings of the National Academy of Sciences

Activated human B lymphocytes express three CTLA-4 counterreceptors that costimulate T-cell activation.

Vassiliki A. Boussiotis, Gordon J. Freeman, JG Gribben, +3

Proceedings of the National Academy of Sciences

Adaptive Immune SystemT-regulatory CellImmunologyActivated Human BCtla-4 Counterreceptors +17

B7 but not intercellular adhesion molecule-1 costimulation prevents the induction of human alloantigen-specific tolerance.

Vassiliki A. Boussiotis, Gordon J. Freeman, G S Gray, +2

The Journal of Experimental Medicine

Cell AdhesionImmunologyImmunodominanceImmunologic MechanismAntigen Processing +20