Human T-cell clonal anergy is induced by antigen presentation in the absence of B7 costimulation.

Claude Gimmi, G J Freeman, John G. Gribben, +2

Proceedings of the National Academy of Sciences

Adaptive Immune SystemHla ImmunogeneticsImmunologyImmunodominanceImmunologic Mechanism +16

B-cell surface antigen B7 provides a costimulatory signal that induces T cells to proliferate and secrete interleukin 2.

Claude Gimmi, Gordon J. Freeman, JG Gribben, +4

Proceedings of the National Academy of Sciences

Adaptive Immune SystemCellular ImmunologyImmunologyImmunologic MechanismCd4 T Cell Responses +18

Structure, expression, and T cell costimulatory activity of the murine homologue of the human B lymphocyte activation antigen B7.

Gordon J. Freeman, G S Gray, Claude Gimmi, +6

The Journal of Experimental Medicine

Lymphocyte DevelopmentAdaptive Immune SystemT-regulatory CellImmunologyMurine B7 +19

Breast cancer–associated antigen, DF3/MUC1, induces apoptosis of activated human T cells

Claude Gimmi, Briggs Morrison, B. Mainprice, +9

Nature Medicine

Tumor BiologyBreast OncologyCancer ImmunosurveillanceMedicineImmunology +7

CTLA-4 and CD28 mRNA are coexpressed in most T cells after activation. Expression of CTLA-4 and CD28 mRNA does not correlate with the pattern of lymphokine production

Gordon J. Freeman, David B. Lombard, Claude Gimmi, +7

The Journal of Immunology

Murine B7 antigen provides an efficient costimulatory signal for activation of murine T lymphocytes via the T-cell receptor/CD3 complex.

Hans Reiser, Gordon J. Freeman, Z Razi-Wolf, +3

Proceedings of the National Academy of Sciences

Adaptive Immune SystemT-regulatory CellImmunologyMurine B7Immunologic Mechanism +16

Differential Effect on Bone Lesions of Targeting Integrins: Randomized Phase II Trial of Abituzumab in Patients with Metastatic Castration-Resistant Prostate Cancer

Maha Hussain, Sylvestre Le Moulec, Claude Gimmi, +3

Clinical Cancer Research

Targeting her-2/neu with antirat Neu virosomes for cancer therapy.

Ernst R. Waelti, Nina Wegmann, Ruth Schwaninger, +4

PubMed

Drug TargetingAttractive TargetMedicinePolymer-drug ConjugateImmunology +13

Targeting HER-2/neu for active-specific immunotherapy in a mouse model of spontaneous breast cancer

Daniel C�fa�, Briggs Morrison, Axel Sckell, +4

International Journal of Cancer

Active-specific ImmunotherapyBreast OncologyImmunologyImmunotherapyCancer Biology +16

The Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Single Oral Doses of CH4987655 in Healthy Volunteers: Target Suppression Using a Biomarker

Lucy Lee, Huifeng Niu, Ruediger Rueger, +14

Clinical Cancer Research