2,4-Diarylpyrrolidine-3-carboxylic AcidsPotent ET_A Selective Endothelin Receptor Antagonists. 1. Discovery of A-127722

Martin Winn, Thomas W von Geldern, Terry J. Opgenorth, +13

Journal of Medicinal Chemistry

Combinatorial ChemistryMolecular PharmacologyMedicinal ChemistryBiochemistryMedicine +10

Identification of Benzoxazin-3-one Derivatives as Novel, Potent, and Selective Nonsteroidal Mineralocorticoid Receptor Antagonists

Tomoaki Hasui, Nobuyuki Matsunaga, Taiichi Ora, +16

Journal of Medicinal Chemistry

Combinatorial ChemistryCrystal StructureMedicinal ChemistryBenzoxazin-3-one DerivativesScaffold Hopping +11

Identification of Novel Inhibitors of Urokinase via NMR-Based Screening

Philip J. Hajduk, Steven A. Boyd, David G. Nettesheim, +6

Journal of Medicinal Chemistry

Medicinal ChemistryDrug TargetPharmaceutical ScienceBiochemistryUrokinase Inhibitors +13

Palladium-catalyzed synthesis of macrocycles. A total synthesis of (-)-aspochalasin B

Barry M. Trost, Masayuki Ohmori, Steven A. Boyd, +2

Journal of the American Chemical Society

Chemical EngineeringEngineeringAltmetric Attention ScoreTotal SynthesisOrganic Chemistry +7

Synthesis, in vitro and in vivo activity of thiamine antagonist transketolase inhibitors

Allen A. Thomas, Yvan Le Huérou, Jason De Meese, +22

Bioorganic & Medicinal Chemistry Letters

Vivo ActivityBiochemistryMedicineMechanism Of ActionPharmacological Agent +5

Selective Inhibition of ICAM-1 and E-Selectin Expression in Human Endothelial Cells. 2. Aryl Modifications of 4-(Aryloxy)thieno[2,3-<i>c</i>]pyridines with Fine-Tuning at C-2 Carbamides

Gui‐Dong Zhu, David L. Arendsen, Indrani W. Gunawardana, +12

Journal of Medicinal Chemistry

Cell AdhesionImmunologyLead MoleculeImmunotherapyE-selectin Expression +17

Discovery of Inhibitors of Cell Adhesion Molecule Expression in Human Endothelial Cells. 1. Selective Inhibition of ICAM-1 and E-Selectin Expression

Andrew O. Stewart, Pramila Bhatia, Catherine M. McCarty, +18

Journal of Medicinal Chemistry

Cell AdhesionImmunologyPharmacotherapyE-selectin ExpressionInflammation +19

Discovery of VNRX-7145 (VNRX-5236 Etzadroxil): An Orally Bioavailable β-Lactamase Inhibitor for Enterobacterales Expressing Ambler Class A, C, and D Enzymes

Robert E. Lee Trout, Allison L. Zulli, Eugen F. Mesaros, +15

Journal of Medicinal Chemistry

Non-charged thiamine analogs as inhibitors of enzyme transketolase

Allen A. Thomas, Jason De Meese, Yvan Le Huérou, +19

Bioorganic & Medicinal Chemistry Letters

Non-charged Thiamine AnalogsBiochemistryNatural SciencesEnzyme CatalysisChemical Biology +2

C-Terminal modifications of nonpeptide renin inhibitors: improved oral bioavailability via modification of physicochemical properties

Steven A. Boyd, Anthony K. L. Fung, William R. Baker, +6

Journal of Medicinal Chemistry